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Rivanicline 2HCl

Name: Rivanicline 2HCl
Brand: TargetMol
SKU: T12738L1
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12738L1

Alias Rivanicline 2HCl(15585-43-0 Free base)

Rivanicline 2HCl is a selective neuronal nicotinic receptor inhibitor with a high affinity for the α4β2 subtype.

Rivanicline 2HCl

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Purity: 99.84%

Catalog No. T12738L1Alias Rivanicline 2HCl(15585-43-0 Free base)

Rivanicline 2HCl is a selective neuronal nicotinic receptor inhibitor with a high affinity for the α4β2 subtype.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$68	In Stock
10 mg	$107	In Stock
25 mg	$259	In Stock
50 mg	$467	In Stock
100 mg	$685	In Stock
1 mL x 10 mM (in DMSO)	$118	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.84%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Rivanicline 2HCl is a selective neuronal nicotinic receptor inhibitor with a high affinity for the α4β2 subtype.
In vitro	The study investigates the impact of selectively inhibiting Akt in proliferating cells that express Trop-2. In cells expressing Trop-2, Akt inhibition, whether achieved through silencing or specific drugs, significantly reduces cell proliferation in a dose-dependent manner.[1]
In vivo	When Trop-2-expressing tumors are subcutaneously injected into animal models, they exhibit a remarkable reduction in growth upon treatment with specific drugs targeting Akt activity. This underscores the central functional role of Akt in mediating the Trop-2-dependent growth stimulus.[1]
Synonyms	Rivanicline 2HCl(15585-43-0 Free base)

Chemical Properties

Molecular Weight	235.15
Formula	C₁₀H₁₆Cl₂N₂
Smiles	CNCC/C=C/C1=CN=CC=C1.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (212.63 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2526 mL	21.2630 mL	42.5260 mL	212.6302 mL
5 mM	0.8505 mL	4.2526 mL	8.5052 mL	42.5260 mL
10 mM	0.4253 mL	2.1263 mL	4.2526 mL	21.2630 mL
20 mM	0.2126 mL	1.0632 mL	2.1263 mL	10.6315 mL
50 mM	0.0851 mL	0.4253 mL	0.8505 mL	4.2526 mL
100 mM	0.0425 mL	0.2126 mL	0.4253 mL	2.1263 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc