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Rivanicline 2HCl

Name: Rivanicline 2HCl
Brand: TargetMol
SKU: T12738L1
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12738L1

Alias Rivanicline 2HCl(15585-43-0 Free base)

Rivanicline 2HCl is a selective neuronal nicotinic receptor inhibitor with a high affinity for the α4β2 subtype.

Rivanicline 2HCl

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Purity: 99.4%

Catalog No. T12738L1Alias Rivanicline 2HCl(15585-43-0 Free base)

Rivanicline 2HCl is a selective neuronal nicotinic receptor inhibitor with a high affinity for the α4β2 subtype.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	-	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$107	In Stock	In Stock
25 mg	$259	-	In Stock
50 mg	$467	-	In Stock
100 mg	$685	-	In Stock
1 mL x 10 mM (in DMSO)	$118	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.4%

Appearance:Oil

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Rivanicline 2HCl is a selective neuronal nicotinic receptor inhibitor with a high affinity for the α4β2 subtype.
In vitro	The study investigates the impact of selectively inhibiting Akt in proliferating cells that express Trop-2. In cells expressing Trop-2, Akt inhibition, whether achieved through silencing or specific drugs, significantly reduces cell proliferation in a dose-dependent manner.[1]
In vivo	When Trop-2-expressing tumors are subcutaneously injected into animal models, they exhibit a remarkable reduction in growth upon treatment with specific drugs targeting Akt activity. This underscores the central functional role of Akt in mediating the Trop-2-dependent growth stimulus.[1]
Synonyms	Rivanicline 2HCl(15585-43-0 Free base)

Chemical Properties

Molecular Weight	235.15
Formula	C₁₀H₁₆Cl₂N₂
Smiles	CNCC/C=C/C1=CN=CC=C1.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (212.63 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2526 mL	21.2630 mL	42.5260 mL	212.6302 mL
5 mM	0.8505 mL	4.2526 mL	8.5052 mL	42.5260 mL
10 mM	0.4253 mL	2.1263 mL	4.2526 mL	21.2630 mL
20 mM	0.2126 mL	1.0632 mL	2.1263 mL	10.6315 mL
50 mM	0.0851 mL	0.4253 mL	0.8505 mL	4.2526 mL
100 mM	0.0425 mL	0.2126 mL	0.4253 mL	2.1263 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc