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GPCR/G Protein

Cholecystokinin Receptor

Melanin-concentrating Hormone Receptor (MCHR)

(34)

Melanocortin Receptor

Neuropeptide FF Receptor

(9)

Neuropeptide W

(3)

Neuropeptide Y Receptor

Prostaglandin Receptor

(434)

Protease-activated Receptor

Succinate Receptor 1 (SUCNR1)

Neuroscience

AAK1 (AP2 associated kinase 1)

Melanocortin Receptor

Neuropeptide Y Receptor

Serotonin Transporter

(124)

iGluR

(401)

P2Y Receptor

P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as adenosine triphosphate, adenosine diphosphate, uridine triphosphate, uridine diphosphate, and UDP-glucose.To date, 8 P2Y receptors have been cloned in humans: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14. P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G-protein coupling. P2Y receptors mediate responses including vasodilation, blood clotting, and immune response. Due to their ubiquity and variety in function, they are a common biological target in pharmacological development.

Filter HomeSignaling PathwaysNeuroscience-GPCR/G ProteinP2Y Receptor

PSB-16133 sodium

T284632089035-40-3In house

PSB-16133 sodium is a selective P2Y purine receptor variant antagonist with an IC of 233 nM.

$293

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SYL-4

T836376222-65-7In house

SYL-4 is a potential P2Y12 receptor antagonist with a Ki value of 7.35 ± 1.72 for use in synthetic dyes.

$882

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MRS 2578

T6172711019-86-2

MRS2578, an effective P2Y6 receptor antagonist with IC50 of 37 nM, shows insignificant inhibition at P2Y1, P2Y2, P2Y4, and P2Y11 receptors.

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Uridine 5′-diphosphoglucose disodium salt

T474328053-08-9

Uridine 5′-diphosphoglucose disodium salt (UDP-Glucose sodium salt) is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It is an agonist of the P2Y14 receptor (EC50 = 0.35 μM) and can also bind to and activate GPR17, inducing oligodendrocyte differentiation at a maximal concentration of 100 μM.

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BPTU

T4132870544-59-5

BPTU (BMS-646786) is an allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle. Blocks inhibition of spontaneous contraction of rat and mouse colon induced by electrical field stimulation, nicotine and P2Y agonists. Antithrombotic; reduces platelet aggregation.

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Cited

PPTN hydrochloride

T635341992047-65-0In house

PPTN hydrochloride is a potent, high-affinity, competitive, and highly selective P2Y14 receptor antagonist (KB: 434 pM) with no agonist or antagonist activity at P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors, exhibiting anti-inflammatory and anti-immune effects.

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Ticagrelor

T0179274693-27-5

Ticagrelor (AR-C 126532XX), produced by AstraZeneca, is an inhibitor of platelet aggregation. Unlike clopidogrel, ticagrelor is not a prodrug required metabolic activation. The drug was approved for use in the European Union by the European Commission on December 3, 2010, and by the US FDA on July 20, 2011. Its trade names are Brilinta (US), Brilique(EU) and Possia(EU).

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cangrelor tetrasodium

T5036163706-36-3

Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects.

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Clopidogrel hydrogen sulfate

T0182L120202-66-6

Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets and platelet adhesion and aggregation.

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Clopidogrel thiolactone

T55011147350-75-1

Clopidogrel thiolactone (2-oxoclopidogrel) is a potent P2Y12 receptor inhibitor and a potent antiplatelet aggregation compound.Clopidogrel thiolactone is the active metabolic intermediate resulting from the first oxidative activation of Clopidogrel.

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Diquafosol tetrasodium

T7423211427-08-6

Diquafosol Tetrasodium is a P2Y2 receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium (INS365) improves tear film stability and visual function, as a topical treatment of dry eye disease.

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Clopidogrel

T0182113665-84-2

Clopidogrel (SR-25990C), a P2Y12 receptor antagonist, decreases platelet aggregation.

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Uridine-5'-diphosphate disodium salt

T470627821-45-0

Uridine-5'-diphosphate disodium salt (UDP disodium salt) is a specific agonist of the P2Y6 receptors (EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstriction. Uridine-5'-diphosphate disodium salt also acts as an antagonist of P2Y14.

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ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate

T98872738381-94-5

ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate is a platelet aggregation inhibitor.

$103

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Selatogrel

T713641159500-34-1

Selatogrel (ACT-246475) is a selective and potent P2Y12 receptor antagonist with antithrombotic activity and inhibition of platelet aggregation for the study of acute myocardial infarction.

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Prasugrel

T0230150322-43-3

Prasugrel (CS-747) is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANGINA and MYOCARDIAL INFARCTION, as well as in those undergoing PERCUTANEOUS CORONARY INTERVENTIONS.

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Sodium metatungstate

T1251912141-67-2

Sodium metatungstate (Sodium polyoxotungstate) is a potent inhibitor of ecto-nucleoside triphosphate diphosphohydrolase (NTPDase), with Ki values of 2.58 μM for NTPDase 1, 3.26 μM for NTPDase 3, and 28.8 μM for NTPDase 2.

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Uridine triphosphate trisodium salt

T839319817-92-6

Uridine triphosphate trisodium salt (UTP, Trisodium Salt) is a nucleotide.

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Elinogrel

T11177936500-94-6In house

Elinogrel (PRT060128) is a competitive and reversible antagonist of platelet P2Y12 with IC50 of 20 nM and exhibits potent antiplatelet effects.

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N6-(4-Hydroxybenzyl)adenosine

T12164110505-75-4In house

N6-(4-Hydroxybenzyl)adenosine (Para-topolin riboside) is a platelet aggregation inhibitor.

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PIT

T2316456583-49-4

PIT (2,2'-Pyridylisatogen tosylate) is a specific, non-competitive antagonist of the Purinergic receptor P2Y1, exhibiting an IC50 of 0.14 μM for human P2Y1. It does not affect nucleotide binding and is useful in studies related to chronic bronchitis and asthma.

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PSB-0739

T231951052087-90-7

PSB-0739 Selective platelet P2Y12 receptor antagonist characterized by competitive binding and high affinity (Ki =24.9 nM) with antithrombotic and platelet aggregation modulating effects.

7-10 days

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PPTN

T125301160271-30-6In house

PPTN is a high-affinity, competitive and highly selective antagonist of P2Y14 receptor(KB value of 434 pM), with anti-inflammatory and immune activity.

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UDP-a-D-Galactose disodium salt

T9369L137868-52-1

UDP-a-D-Galactose disodium salt is a donor substrate for galactosyltransferases employed in the biosynthesis of galactose-containing oligosaccharides[1].

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