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Compound C108

Catalog No. T38387 CAS 15533-09-2

Compound C108 is an inhibitor of GTPase-activating protein SH3 domain-binding protein 2 (G3BP2). Compound C108 can be used in studies about breast tumors and esophageal squamous cell carcinoma.

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Compound C108, CAS 15533-09-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
5 mg	In stock	$ 82.00
10 mg	In stock	$ 132.00
25 mg	In stock	$ 265.00
50 mg	In stock	$ 423.00
100 mg	In stock	$ 628.00
500 mg	In stock	$ 1,350.00
1 mL * 10 mM (in DMSO)	In stock	$ 127.00

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Purity: 99.77%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Compound C108 is an inhibitor of GTPase-activating protein SH3 domain-binding protein 2 (G3BP2). Compound C108 can be used in studies about breast tumors and esophageal squamous cell carcinoma.
In vitro	In BT474 cells, Compound C108 (1 μM) shows anti-tumor activity[1]. In G3BP2 overexpressing KYSE410 cells and LINC01554 transfected KYSE30 cells, Compound C108 (4 μM) reduces the protein expression of G3BP2 and attenuates ESCC cell metastasis, migration and invasion[2].
In vivo	In a mouse xenograft model of breast cancer, compound C108 (1 μM) reduces the proportion of tumor-initiating cells approximately 10-fold[1].

Molecular Weight	270.28
Formula	C15H14N2O3
CAS No.	15533-09-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF:PBS(pH 7.2)(1:6): 0.14 mg/mL

DMF: 1 mg/mL

DMSO: 22.5 mg/mL (83.2 mM), Sonification is recommended.

References and Literature

1. Gupta N, et al. Stress granule-associated protein G3BP2 regulates breast tumor initiation. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1033-1038. 2. Zheng Y, et al. G3BP2 regulated by the lncRNA LINC01554 facilitates esophageal squamous cell carcinoma metastasis through stabilizing HDGF transcript. Oncogene. 2022 Jan;41(4):515-526.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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BQU57 RBC8 CID-4785700 Exo-1 NAV-2729 CCG 203769 Dynamin inhibitory peptide Acetate CCG-63802

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Compound C108 15533-09-2 GPCR/G Protein GTPase Compound C-108 Compound C 108 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.