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DDR1 Protein, Human, Recombinant (aa 21-417, His)
(Synonyms: Tyrosine-protein kinase CAK, Tyrosine kinase DDR, TRKE, TRK E, RTK6, PTK3A, Protein-tyrosine kinase RTK-6, Protein-tyrosine kinase 3A, NTRK4, NEP, Mammary carcinoma kinase 10 (MCK-10), HGK2, Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, EDDR1, Discoidin receptor tyrosine kinase, DDR1, Cell adhesion kinase, CD167a, CD167 antigen-like family member A, CAK) Copy Product InfoSynonyms: Tyrosine-protein kinase CAK, Tyrosine kinase DDR, TRKE, TRK E, RTK6, PTK3A, Protein-tyrosine kinase RTK-6, Protein-tyrosine kinase 3A, NTRK4, NEP, Mammary carcinoma kinase 10 (MCK-10), HGK2, Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, EDDR1, Discoidin receptor tyrosine kinase, DDR1, Cell adhesion kinase, CD167a, CD167 antigen-like family member A, CAK
Catalog No. TMPH-01297 Copy Product Info
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $43 | 20 days | 20 days | |
| 10 µg | $66 | 20 days | 20 days | |
| 20 µg | $106 | 20 days | 20 days | |
| 50 µg | $189 | 20 days | 20 days | |
| 100 µg | $297 | 20 days | 20 days | |
| 200 µg | $519 | 20 days | 20 days | |
| 500 µg | $1,090 | 20 days | 20 days | |
| 1 mg | $1,930 | 20 days | 20 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Measured by its binding ability in a functional ELISA. Immobilized Human DDR1 at 2 μg/mL can bind Anti-DDR1 recombinant antibody, the EC 50 is 2.824-3.810 ng/mL. |
| Description | Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-10xHis |
| Accession Number | Q08345 |
| Amino Acid | DMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTA |
| Construction | 21-417 aa |
| Protein Purity | > 95% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0 |
| Reconstitution | Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | Tyrosine-protein kinase CAK, Tyrosine kinase DDR, TRKE, TRK E, RTK6, PTK3A, Protein-tyrosine kinase RTK-6, Protein-tyrosine kinase 3A, NTRK4, NEP, Mammary carcinoma kinase 10 (MCK-10), HGK2, Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, EDDR1, Discoidin receptor tyrosine kinase, DDR1, Cell adhesion kinase, CD167a, CD167 antigen-like family member A, CAK |
| Research Background | Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. |
| Molecular Weight | 46.8 kDa (predicted) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: DDR1 Protein, Human, Recombinant (aa 21-417, His) chemical structure | DDR1 Protein, Human, Recombinant (aa 21-417, His) molecular weight
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