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DDR1 Protein, Human, Recombinant (aa 21-417, His)

Catalog No. TMPH-01297
Synonyms: EDDR1, MCK-10, Epithelial discoidin domain-containing receptor 1, CD167a, Cell adhesion kinase, CD167 antigen-like family member A, NTRK4, PTK3A, NEP, RTK6, TRKE, Discoidin receptor tyrosine kinase, CAK, HGK2, Epithelial discoidin domain receptor 1, Mammary carcinoma kinase 10, DDR1

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
DDR1 Protein, Human, Recombinant (aa 21-417, His)
Pack Size Availability Price/USD Quantity
20 μg 20 days $ 211.00
100 μg 20 days $ 397.00
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Biological Description
Technical Params
Product Properties
Description Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
Species Human
Expression System HEK293
Tag C-terminal 10xHis-tagged
Accession Number Q08345
Synonyms EDDR1, MCK-10, Epithelial discoidin domain-containing receptor 1, CD167a, Cell adhesion kinase, CD167 antigen-like family member A, NTRK4, PTK3A, NEP, RTK6, TRKE, Discoidin receptor tyrosine kinase, CAK, HGK2, Epithelial discoidin domain receptor 1, Mammary carcinoma kinase 10, DDR1
Amino Acid DMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTA
Construction 21-417 aa
Protein Purity > 95% as determined by SDS-PAGE.
Molecular Weight 46.8 kDa as predicted
Endotoxin < 1.0 EU per μg protein as determined by the LAL method.
Formulation Lyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
Reconstitution A hardcopy of COA with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage

Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

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Keywords

DDR1 Protein, Human, Recombinant (aa 21-417, His) EDDR1 MCK-10 Epithelial discoidin domain-containing receptor 1 CD167a Cell adhesion kinase CD167 antigen-like family member A NTRK4 PTK3A NEP RTK6 TRKE Discoidin receptor tyrosine kinase CAK HGK2 Epithelial discoidin domain receptor 1 Mammary carcinoma kinase 10 DDR1 recombinant recombinant-proteins proteins protein

 

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