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COQ7-IN-1

Name: COQ7-IN-1
Brand: TargetMol
SKU: T35861
Rating: 4.5 (1 reviews)

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Catalog No. T35861Cas No. 2579696-72-1

Alias COQ7-IN-1

COQ7-IN-1 is a powerful inhibitor of human coenzyme Q (COQ7), effectively disrupting the synthesis of ubiquinone (UQ) in the body. Notably, COQ7-IN-1 does not disrupt the natural growth of human normal culture cells. This compound proves valuable for investigating the equilibrium between two pathways of UQ supplementation: de novo UQ synthesis and extracellular UQ uptake[1].

COQ7-IN-1

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Catalog No. T35861Alias COQ7-IN-1Cas No. 2579696-72-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$58	5 days	5 days
1 mL x 10 mM (in DMSO)	$98	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	COQ7-IN-1 is a powerful inhibitor of human coenzyme Q (COQ7), effectively disrupting the synthesis of ubiquinone (UQ) in the body. Notably, COQ7-IN-1 does not disrupt the natural growth of human normal culture cells. This compound proves valuable for investigating the equilibrium between two pathways of UQ supplementation: de novo UQ synthesis and extracellular UQ uptake[1].
In vitro	COQ7-IN-1 (Compound 8; 0-30 μM; for 4 days) inhibits WI-38 cell growth with a GI50 of 19.0 μM and weakly inhibits C3A cell growth with a GI50 of 9.0±1.1 μM, without affecting C3A cell survival via inhibition of aerobic respiration or increased oxidative stress[1]. COQ7 converts demethoxy-UQ (DMQ) to demethyl-UQ (DMeQ), which is then converted to UQ by COQ3. Cells deficient in COQ7 cannot produce UQ, leading to DMQ accumulation. DMQ10 and UQ10 contents in COQ7-IN-1 (10 μM; for 2 days) cultured HeLa cells are 13.2 and 12.2 ng/well, respectively, with a DMQ10 content of 52.0%[1].
Synonyms	COQ7-IN-1

Chemical Properties

Molecular Weight	271.7
Formula	C₁₄H₁₀ClN₃O
Cas No.	2579696-72-1
Smiles	Oc1cc(nn1-c1ccc(Cl)cn1)-c1ccccc1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (368.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (12.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6805 mL	18.4026 mL	36.8053 mL	184.0265 mL
5 mM	0.7361 mL	3.6805 mL	7.3611 mL	36.8053 mL
10 mM	0.3681 mL	1.8403 mL	3.6805 mL	18.4026 mL
20 mM	0.1840 mL	0.9201 mL	1.8403 mL	9.2013 mL
50 mM	0.0736 mL	0.3681 mL	0.7361 mL	3.6805 mL
100 mM	0.0368 mL	0.1840 mL	0.3681 mL	1.8403 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc