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COQ7-IN-1

Name: COQ7-IN-1
Brand: TargetMol
SKU: T35861
Rating: 4.5 (1 reviews)

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Catalog No. T35861Cas No. 2579696-72-1

Alias COQ7-IN-1

COQ7-IN-1 is a powerful inhibitor of human coenzyme Q (COQ7), effectively disrupting the synthesis of ubiquinone (UQ) in the body. Notably, COQ7-IN-1 does not disrupt the natural growth of human normal culture cells. This compound proves valuable for investigating the equilibrium between two pathways of UQ supplementation: de novo UQ synthesis and extracellular UQ uptake[1].

COQ7-IN-1

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Catalog No. T35861Alias COQ7-IN-1Cas No. 2579696-72-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$58	5 days	5 days
1 mL x 10 mM (in DMSO)	$98	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	COQ7-IN-1 is a powerful inhibitor of human coenzyme Q (COQ7), effectively disrupting the synthesis of ubiquinone (UQ) in the body. Notably, COQ7-IN-1 does not disrupt the natural growth of human normal culture cells. This compound proves valuable for investigating the equilibrium between two pathways of UQ supplementation: de novo UQ synthesis and extracellular UQ uptake[1].
In vitro	COQ7-IN-1 (Compound 8; 0-30 μM; for 4 days) inhibits WI-38 cell growth with a GI50 of 19.0 μM and weakly inhibits C3A cell growth with a GI50 of 9.0±1.1 μM, without affecting C3A cell survival via inhibition of aerobic respiration or increased oxidative stress[1]. COQ7 converts demethoxy-UQ (DMQ) to demethyl-UQ (DMeQ), which is then converted to UQ by COQ3. Cells deficient in COQ7 cannot produce UQ, leading to DMQ accumulation. DMQ10 and UQ10 contents in COQ7-IN-1 (10 μM; for 2 days) cultured HeLa cells are 13.2 and 12.2 ng/well, respectively, with a DMQ10 content of 52.0%[1].
Synonyms	COQ7-IN-1

Chemical Properties

Molecular Weight	271.7
Formula	C₁₄H₁₀ClN₃O
Cas No.	2579696-72-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (368.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (12.15 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6805 mL	18.4026 mL	36.8053 mL	184.0265 mL
5 mM	0.7361 mL	3.6805 mL	7.3611 mL	36.8053 mL
10 mM	0.3681 mL	1.8403 mL	3.6805 mL	18.4026 mL
20 mM	0.1840 mL	0.9201 mL	1.8403 mL	9.2013 mL
50 mM	0.0736 mL	0.3681 mL	0.7361 mL	3.6805 mL
100 mM	0.0368 mL	0.1840 mL	0.3681 mL	1.8403 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc