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Anti-Mucin-1/MUC1 Antibody (3B484)
🥰Excellent
Catalog No. TMAY-02247
Anti-Mucin-1/MUC1 Antibody (3B484) is a Rabbit antibody targeting Mucin-1/MUC1. Anti-Mucin-1/MUC1 Antibody (3B484) can be used in IHC-P.
Anti-Mucin-1/MUC1 Antibody (3B484)
Anti-Mucin-1/MUC1 Antibody (3B484)
🥰Excellent
Catalog No. TMAY-02247
Anti-Mucin-1/MUC1 Antibody (3B484) is a Rabbit antibody targeting Mucin-1/MUC1. Anti-Mucin-1/MUC1 Antibody (3B484) can be used in IHC-P.
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Related Conjugates and Formulations
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Chemical Properties
| Description | Anti-Mucin-1/MUC1 Antibody (3B484) is a Rabbit antibody targeting Mucin-1/MUC1. Anti-Mucin-1/MUC1 Antibody (3B484) can be used in IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 3B484 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human MUC1 in human breast with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of human MUC1 in human kidney with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. 3. Immunochemical staining of human MUC1 in human squamous cell carcinoma with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human MUC1 (rh MUC1; NP_001018016.1; Met1-Gly167). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Mucin 1, cell surface-associated (MUC1) or polymorphic epithelial mucin (PEM) is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach, and pancreas. MUC-1/CC1/CD227 Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized, and recycled to the cell membrane. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. The alpha subunit has cell adhesive properties. MUC-1/CC1/CD227 Can act both as an adhesion and an anti-adhesion protein. This protein May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. MUC-1/CC1/CD227 participated in modulates signaling in ERK, SRC, and NF-kappa-B pathways. In the activated T-cells, MUC-1/CC1/CD227 influences directly or indirectly the Ras/MAPK pathway. MUC-1/CC1/CD227 Promotes tumor progression and regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human MUC1 Protein |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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