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Midaglizole hydrochloride

Name: Midaglizole hydrochloride
Brand: TargetMol
SKU: T11015
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11015Cas No. 79689-25-1

Alias DG5128 hydrochloride, (±)-DG5128 hydrochloride

Midaglizole hydrochloride ((±)-DG5128) (DG5128) is a preferred α2-adrenoceptor antagonist. Midazolazole hydrochloride (DG5128) has an affinity for α2-adrenoceptor (pKi = 6.28) 7.4 times higher than that of α1-adrenoceptor.

Midaglizole hydrochloride

🥰Excellent

Purity: 99.82%

Catalog No. T11015Alias DG5128 hydrochloride, (±)-DG5128 hydrochlorideCas No. 79689-25-1

Pack Size	Price	Availability
1 mg	$52	In Stock
5 mg	$128	In Stock
10 mg	$209	In Stock
25 mg	$341	In Stock
50 mg	$463	In Stock
100 mg	$592	In Stock
200 mg	$783	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.82%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Midaglizole hydrochloride ((±)-DG5128) (DG5128) is a preferred α2-adrenoceptor antagonist. Midazolazole hydrochloride (DG5128) has an affinity for α2-adrenoceptor (pKi = 6.28) 7.4 times higher than that of α1-adrenoceptor.
Targets&IC50	α2-adrenoceptor:6.28(pKi )
In vitro	The inhibitory effect of midazolam (DG-5128) at a concentration of up to 10 μM in the cerebral cerebral membrane of [3H] clonidine is more effective than that of [3H] prazosin. The suppression method is uniform and conforms to the simple law of mass action. The EC50 values of midazolazole-induced insulin release in rat pancreatic islets and MIN6β cell lines were 200 nM and 24 μM, respectively. The IC50 values of midazolam for Kir6.2 and Kir6.2/SUR1 induced KATP current were 3.8 μM and 4.4 uM, respectively.
In vivo	Midaglizole (3 and 30 mg/kg, i.v.) elevates blood pressure in pithed rats[1].
Synonyms	DG5128 hydrochloride, (±)-DG5128 hydrochloride

Chemical Properties

Molecular Weight	324.25
Formula	C₁₆H₁₉Cl₂N₃
Cas No.	79689-25-1
Smiles	C1(C(CC2=NCCN2)C3=CC=CC=C3)=NC=CC=C1.Cl.Cl
Relative Density.	1.31g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (138.78 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0840 mL	15.4202 mL	30.8404 mL	154.2020 mL
5 mM	0.6168 mL	3.0840 mL	6.1681 mL	30.8404 mL
10 mM	0.3084 mL	1.5420 mL	3.0840 mL	15.4202 mL
20 mM	0.1542 mL	0.7710 mL	1.5420 mL	7.7101 mL
50 mM	0.0617 mL	0.3084 mL	0.6168 mL	3.0840 mL
100 mM	0.0308 mL	0.1542 mL	0.3084 mL	1.5420 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc