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Midaglizole hydrochloride

Name: Midaglizole hydrochloride
Brand: TargetMol
SKU: T11015
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11015Cas No. 79689-25-1

Alias DG5128 hydrochloride, (±)-DG5128 hydrochloride

Midaglizole hydrochloride ((±)-DG5128) (DG5128) is a preferred α2-adrenoceptor antagonist. Midazolazole hydrochloride (DG5128) has an affinity for α2-adrenoceptor (pKi = 6.28) 7.4 times higher than that of α1-adrenoceptor.

Midaglizole hydrochloride

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Purity: 99.82%

Catalog No. T11015Alias DG5128 hydrochloride, (±)-DG5128 hydrochlorideCas No. 79689-25-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	-	In Stock
5 mg	$128	-	In Stock
10 mg	$209	-	In Stock
25 mg	$341	-	In Stock
50 mg	$463	-	In Stock
100 mg	$592	-	In Stock
200 mg	$783	-	In Stock
1 mL x 10 mM (in DMSO)	$163	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.82%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Midaglizole hydrochloride ((±)-DG5128) (DG5128) is a preferred α2-adrenoceptor antagonist. Midazolazole hydrochloride (DG5128) has an affinity for α2-adrenoceptor (pKi = 6.28) 7.4 times higher than that of α1-adrenoceptor.
Targets&IC50	α2-adrenoceptor:6.28(pKi )
In vitro	The inhibitory effect of midazolam (DG-5128) at a concentration of up to 10 μM in the cerebral cerebral membrane of [3H] clonidine is more effective than that of [3H] prazosin. The suppression method is uniform and conforms to the simple law of mass action. The EC50 values of midazolazole-induced insulin release in rat pancreatic islets and MIN6β cell lines were 200 nM and 24 μM, respectively. The IC50 values of midazolam for Kir6.2 and Kir6.2/SUR1 induced KATP current were 3.8 μM and 4.4 uM, respectively.
In vivo	Midaglizole (3 and 30 mg/kg, i.v.) elevates blood pressure in pithed rats[1].
Synonyms	DG5128 hydrochloride, (±)-DG5128 hydrochloride

Chemical Properties

Molecular Weight	324.25
Formula	C₁₆H₁₉Cl₂N₃
Cas No.	79689-25-1
Smiles	C1(C(CC2=NCCN2)C3=CC=CC=C3)=NC=CC=C1.Cl.Cl
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (138.78 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0840 mL	15.4202 mL	30.8404 mL	154.2020 mL
5 mM	0.6168 mL	3.0840 mL	6.1681 mL	30.8404 mL
10 mM	0.3084 mL	1.5420 mL	3.0840 mL	15.4202 mL
20 mM	0.1542 mL	0.7710 mL	1.5420 mL	7.7101 mL
50 mM	0.0617 mL	0.3084 mL	0.6168 mL	3.0840 mL
100 mM	0.0308 mL	0.1542 mL	0.3084 mL	1.5420 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc