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PGN-9856

Name: PGN-9856
Brand: TargetMol
SKU: T68514
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T68514Cas No. 863704-91-0

Alias PGN9856

PGN-9856 is a selective and high-affinity EP2 receptor ligand, a selective EP2 receptor agonist with anti-inflammatory and intraocular pressure-lowering properties. It can be used in glaucoma research.

PGN-9856

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Purity: 99.27%

Catalog No. T68514Alias PGN9856Cas No. 863704-91-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	-	In Stock
5 mg	$162	-	In Stock
10 mg	$238	-	In Stock
25 mg	$392	-	In Stock
50 mg	$593	-	In Stock
100 mg	$858	-	In Stock
200 mg	$1,150	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.27%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	PGN-9856 is a selective and high-affinity EP2 receptor ligand, a selective EP2 receptor agonist with anti-inflammatory and intraocular pressure-lowering properties. It can be used in glaucoma research.
Targets&IC50	EP2:≥ 8.5 (pEC50), EP2:≥ 8.3 (pKi)
In vitro	PGN-9856 is a selective, high-affinity (pKi ≥ 8.3) human recombinant EP2 receptor ligand. [1]
In vivo	PGN-9856 has uterine contraction inhibition, anti-inflammatory and long-term IOP lowering properties. [1]
Synonyms	PGN9856

Chemical Properties

Molecular Weight	383.35
Formula	C₂₁H₁₅F₂NO₄
Cas No.	863704-91-0
Smiles	O=C(O)COC1=CC=CC(=C1)NC(=O)C=2C=C(C=CC2F)C3=CC=CC(F)=C3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (260.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6086 mL	13.0429 mL	26.0858 mL	130.4291 mL
5 mM	0.5217 mL	2.6086 mL	5.2172 mL	26.0858 mL
10 mM	0.2609 mL	1.3043 mL	2.6086 mL	13.0429 mL
20 mM	0.1304 mL	0.6521 mL	1.3043 mL	6.5215 mL
50 mM	0.0522 mL	0.2609 mL	0.5217 mL	2.6086 mL
100 mM	0.0261 mL	0.1304 mL	0.2609 mL	1.3043 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc