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Dazostinag disodium

Name: Dazostinag disodium
Brand: TargetMol
SKU: T72482
Price: 498 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72482Cas No. 2553413-93-5

Dazostinag disodium (TAK-676) is a synthetic novel interferon gene (STING) agonist that triggers STING signaling pathway activation and type I interferon activation. Dazostinag disodium (TAK-676) is also a highly effective immune system modulator with complete resolution and lasting memory of T cell immunity and the ability to promote lasting interferon-dependent anti-tumor immune responses.

Dazostinag disodium

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Purity: 99.96%

Catalog No. T72482Cas No. 2553413-93-5

Pack Size	Price	USA Warehouse	Global Warehouse
100 μg	$498	In Stock	In Stock
500 μg	$998	In Stock	In Stock
1 mg	$1,650	In Stock	In Stock
5 mg	$3,280	In Stock	In Stock
25 mg	$7,630	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.96%

Appearance:Solid

Color:White

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COA HNMR IC LCMS

Product Introduction

Bioactivity

Description	Dazostinag disodium (TAK-676) is a synthetic novel interferon gene (STING) agonist that triggers STING signaling pathway activation and type I interferon activation. Dazostinag disodium (TAK-676) is also a highly effective immune system modulator with complete resolution and lasting memory of T cell immunity and the ability to promote lasting interferon-dependent anti-tumor immune responses.
Targets&IC50	CD4+:0.249 μM, natural killer cell:0.271 μM, CD8+:0.216 μM
In vitro	METHODS: The ability of TAK-676 to activate the STING pathway was evaluated in human THP1-Dual and mouse CT26 cells treated with dazostinag disodium (TAK-676) (1.1, 3.3, 10 μM, 2 hours). RESULTS Expression of pSTING (S366), pTBK1 (S172), and pIRF3 (S396) was dose-dependently induced in both mouse and human cell lines. [1]
In vivo	METHODS: Mice were injected subcutaneously into the right flank with CT26, WT tumor cells, A20 tumor cells, or B16F10 tumor cells, and Dazostinag disodium (TAK-676) (0.3, 1.0, 2.0 mg/kg, intravenously, once every three days, 3 times), and the effects on tumor growth were evaluated by measuring growth rate inhibition (GRI) and tumor regression. RESULTS When Dazostinag disodium (TAK-676) was administered at a dose of 1 mg/kg, BALB/c mice bearing A20 syngeneic tumors showed significant antitumor activity compared to vehicle treatment (GRI 72%, P < 0.001); similar to the A20 tumor model, CT26 tumor-bearing animals treated with 1 mg/kg of Dazostinag disodium (TAK-676) also showed tumor control over vehicle-treated animals; when the dose of Dazostinag disodium (TAK-676) was increased from 1.0 to 2.0 mg/kg, the antitumor activity was significantly increased in both the A20 (GRI=91%, P < 0.001) and CT26 (GRI=132%, P < 0.001) models. [1]

Chemical Properties

Molecular Weight	754.48
Formula	C₂₁H₂₀F₂N₈Na₂O₁₀P₂S₂
Cas No.	2553413-93-5
Smiles	O[C@H]1[C@@]2([C@@H](O[C@@]1(COP([S-])(O[C@@]3([C@@]([H])(COP([S-])(O2)=O)O[C@H]([C@@H]3F)N4C5=NC=NC(N)=C5N=C4)[H])=O)[H])N6C7=C(C(F)=C6)C(N=CN7)=O)[H].[Na+].[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (331.35 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3254 mL	6.6271 mL	13.2542 mL	66.2708 mL
5 mM	0.2651 mL	1.3254 mL	2.6508 mL	13.2542 mL
10 mM	0.1325 mL	0.6627 mL	1.3254 mL	6.6271 mL
20 mM	0.0663 mL	0.3314 mL	0.6627 mL	3.3135 mL
50 mM	0.0265 mL	0.1325 mL	0.2651 mL	1.3254 mL
100 mM	0.0133 mL	0.0663 mL	0.1325 mL	0.6627 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc