Shopping Cart

Your shopping cart is currently empty

KM02894

Name: KM02894
Brand: TargetMol
SKU: T77581
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T77581Cas No. 116850-74-9

KM02894 is a glutamate release inhibitor. Cancer cells release high levels of glutamate that can disrupt normal bone turnover, which can lead to cancer-induced bone pain.KM02894 may be used in the study of tumor-related diseases.

KM02894

Copy Product Info

🥰Excellent

Purity: 99.98%

Catalog No. T77581Cas No. 116850-74-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.98%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

KM02894 AI Summary

KM02894 exhibits multiple bioactivities with varying potencies. It inhibits tau fibril formation with a potency of 8912.5 nM, HP1-beta chromodomain interactions with methylated histone tails at 79432.8 nM, and Polymerase Iota at 89125.1 nM. It also inhibits TGF-b with a potency of 3548.1 nM and glutaminase (GLS) at 14125.4 nM. Additionally, KM02894 induces DNA re-replication in SW480 colon adenocarcinoma cells at a potency of 4.1 nM and inhibits AMA1-RON, relevant for antimalarial drug development, at 1778.3 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	215.3
Formula	C₇H₉N₃OS₂
Cas No.	116850-74-9
Smiles	CNC(=S)NNC(=O)C1=CC=CS1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (139.34 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6447 mL	23.2234 mL	46.4468 mL	232.2341 mL
5 mM	0.9289 mL	4.6447 mL	9.2894 mL	46.4468 mL
10 mM	0.4645 mL	2.3223 mL	4.6447 mL	23.2234 mL
20 mM	0.2322 mL	1.1612 mL	2.3223 mL	11.6117 mL
50 mM	0.0929 mL	0.4645 mL	0.9289 mL	4.6447 mL
100 mM	0.0464 mL	0.2322 mL	0.4645 mL	2.3223 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc