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Jamaicin

Name: Jamaicin
Brand: TargetMol
SKU: T23735
Price: 127 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23735Cas No. 24211-36-7

Alias AnCoA-4, An-Co-A4, AnCoA4, An Co A4

Jamaicin (AnCoA4), an isoflavone derived from the chickweed plant, is an inhibitor of the STIM1-Orai1 channel that blocks calcium influx, reduces its interaction with STIM1, and inhibits T-cell activation.

Jamaicin

🥰Excellent

Purity: 99.32%

Catalog No. T23735Alias AnCoA-4, An-Co-A4, AnCoA4, An Co A4Cas No. 24211-36-7

Pack Size	Price	Availability
1 mg	$127	In Stock
5 mg	$312	In Stock
10 mg	$488	In Stock
25 mg	$987	In Stock
50 mg	$1,370	In Stock
100 mg	$1,850	In Stock

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Batch Information

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Purity:99.32%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Jamaicin (AnCoA4), an isoflavone derived from the chickweed plant, is an inhibitor of the STIM1-Orai1 channel that blocks calcium influx, reduces its interaction with STIM1, and inhibits T-cell activation.
Targets&IC50	DLD-1 cells (WT):20.9 ± 0.9 μM, DLD-1 DKO cells:> 100 μM
Synonyms	AnCoA-4, An-Co-A4, AnCoA4, An Co A4

Chemical Properties

Molecular Weight	378.37
Formula	C₂₂H₁₈O₆
Cas No.	24211-36-7
Smiles	O=C1C(=COC2=C3C=CC(OC3=CC=C12)(C)C)C=4C=C5OCOC5=CC4OC
Relative Density.	1.332 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.3 mg/mL (58.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6429 mL	13.2146 mL	26.4292 mL	132.1458 mL
5 mM	0.5286 mL	2.6429 mL	5.2858 mL	26.4292 mL
10 mM	0.2643 mL	1.3215 mL	2.6429 mL	13.2146 mL
20 mM	0.1321 mL	0.6607 mL	1.3215 mL	6.6073 mL
50 mM	0.0529 mL	0.2643 mL	0.5286 mL	2.6429 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc