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CDK1-IN-2

Name: CDK1-IN-2
Brand: TargetMol
SKU: T64373
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T64373Cas No. 220749-41-7

Alias cdk1 inhibitor 2

CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM. A broad-spectrum kinase profiling of CDK1-IN-2 revealed nonselective inhibition of several kinases.

CDK1-IN-2

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Purity: 98.53%

Catalog No. T64373Alias cdk1 inhibitor 2Cas No. 220749-41-7

CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM. A broad-spectrum kinase profiling of CDK1-IN-2 revealed nonselective inhibition of several kinases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$46	In Stock	In Stock
5 mg	$109	In Stock	In Stock
10 mg	$178	In Stock	In Stock
25 mg	$372	In Stock	In Stock
50 mg	$597	In Stock	In Stock
100 mg	$852	-	In Stock
500 mg	$1,730	-	In Stock
1 mL x 10 mM (in DMSO)	$105	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.53%

Appearance:Solid

Color:Orange

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM. A broad-spectrum kinase profiling of CDK1-IN-2 revealed nonselective inhibition of several kinases.
Targets&IC50	CDK1:5.8 μM
In vitro	Effect of inhibitors designated CDK1-selective on the cell cycle of HCT-116 cells treated for 24 h, CDK1-IN-2(0-19.8μM) arrested HCT-116 cells in the G2/M phases[1].
Synonyms	cdk1 inhibitor 2

Chemical Properties

Molecular Weight	294.73
Formula	C₁₇H₁₁ClN₂O
Cas No.	220749-41-7
Smiles	Clc1[nH]c2ccccc2c1\C=C1\C(=O)Nc2ccccc12
Relative Density.	1.450 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (763.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (11.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3929 mL	16.9647 mL	33.9294 mL	169.6468 mL
5 mM	0.6786 mL	3.3929 mL	6.7859 mL	33.9294 mL
10 mM	0.3393 mL	1.6965 mL	3.3929 mL	16.9647 mL
20 mM	0.1696 mL	0.8482 mL	1.6965 mL	8.4823 mL
50 mM	0.0679 mL	0.3393 mL	0.6786 mL	3.3929 mL
100 mM	0.0339 mL	0.1696 mL	0.3393 mL	1.6965 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc