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CDK1-IN-2

Name: CDK1-IN-2
Brand: TargetMol
SKU: T64373
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T64373Cas No. 220749-41-7

Alias cdk1 inhibitor 2

CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM. A broad-spectrum kinase profiling of CDK1-IN-2 revealed nonselective inhibition of several kinases.

CDK1-IN-2

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Purity: 98.53%

Catalog No. T64373Alias cdk1 inhibitor 2Cas No. 220749-41-7

CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM. A broad-spectrum kinase profiling of CDK1-IN-2 revealed nonselective inhibition of several kinases.

Pack Size	Price	Availability
1 mg	$46	In Stock
5 mg	$109	In Stock
10 mg	$178	In Stock
25 mg	$372	In Stock
50 mg	$597	In Stock
100 mg	$852	In Stock
500 mg	$1,730	In Stock
1 mL x 10 mM (in DMSO)	$105	In Stock

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Purity:98.53%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM. A broad-spectrum kinase profiling of CDK1-IN-2 revealed nonselective inhibition of several kinases.
Targets&IC50	CDK1:5.8 μM
In vitro	Effect of inhibitors designated CDK1-selective on the cell cycle of HCT-116 cells treated for 24 h, CDK1-IN-2(0-19.8μM) arrested HCT-116 cells in the G2/M phases[1].
Synonyms	cdk1 inhibitor 2

Chemical Properties

Molecular Weight	294.73
Formula	C₁₇H₁₁ClN₂O
Cas No.	220749-41-7
Smiles	Clc1[nH]c2ccccc2c1\C=C1\C(=O)Nc2ccccc12
Relative Density.	1.450 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (763.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3929 mL	16.9647 mL	33.9294 mL	169.6468 mL
5 mM	0.6786 mL	3.3929 mL	6.7859 mL	33.9294 mL
10 mM	0.3393 mL	1.6965 mL	3.3929 mL	16.9647 mL
20 mM	0.1696 mL	0.8482 mL	1.6965 mL	8.4823 mL
50 mM	0.0679 mL	0.3393 mL	0.6786 mL	3.3929 mL
100 mM	0.0339 mL	0.1696 mL	0.3393 mL	1.6965 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc