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LY3177833

Name: LY3177833
Brand: TargetMol
SKU: T7810
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7810Cas No. 1627696-51-8

Alias LY-3177833

LY3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM)

LY3177833

🥰Excellent

Purity: 99.87%

Catalog No. T7810Alias LY-3177833Cas No. 1627696-51-8

LY3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM)

Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$77	In Stock
10 mg	$117	In Stock
25 mg	$235	In Stock
50 mg	$353	In Stock
100 mg	$529	In Stock
200 mg	$753	In Stock
1 mL x 10 mM (in DMSO)	$84	In Stock

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Batch Information

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Purity:99.87%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	LY3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM)
Targets&IC50	CDC7:3.3 nM, pMCM2:290 nM
In vivo	LY-3177833 inhibits phosphorylation of MCM2-S53 in H1299 cells (IC50 = 0.29 μM).?LY3177833 reduces tumor growth in an SW620 human colorectal adenocarcinoma mouse xenograft model when administered at doses of 10, 20, and 30 mg/kg twice per day
Synonyms	LY-3177833

Chemical Properties

Molecular Weight	309.3
Formula	C₁₆H₁₂FN₅O
Cas No.	1627696-51-8
Smiles	C[C@]1(NC(=O)c2cc(ccc12)-c1cn[nH]c1)c1ncncc1F
Relative Density.	1.398 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (96.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2331 mL	16.1655 mL	32.3311 mL	161.6554 mL
5 mM	0.6466 mL	3.2331 mL	6.4662 mL	32.3311 mL
10 mM	0.3233 mL	1.6166 mL	3.2331 mL	16.1655 mL
20 mM	0.1617 mL	0.8083 mL	1.6166 mL	8.0828 mL
50 mM	0.0647 mL	0.3233 mL	0.6466 mL	3.2331 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc