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Guacetisal

Name: Guacetisal
Brand: TargetMol
SKU: T15447
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15447Cas No. 55482-89-8

Guacetisal is extracted from the esterification reaction of acetylsalicylic acid with guaiacol which can be used for research on the treatment of chronic bronchitis.

Guacetisal

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Purity: 99.18%

Catalog No. T15447Cas No. 55482-89-8

Guacetisal is extracted from the esterification reaction of acetylsalicylic acid with guaiacol which can be used for research on the treatment of chronic bronchitis.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$38	In Stock	In Stock
5 mg	$58	In Stock	In Stock
10 mg	$106	In Stock	In Stock
25 mg	$196	In Stock	In Stock
50 mg	$250	In Stock	In Stock
100 mg	$352	-	In Stock
200 mg	$492	-	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.18%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Guacetisal AI Summary

Guacetisal exhibits a range of bioactivities. It inhibits the human intestinal peptide carrier PEPT1 with a Ki value of 90000.0 nM and shows binding affinity in human Caco-2 cells at the same Ki value. It activates human PEPT1 expressed in MDCK cells with an EC50 of 100000.0 nM and achieves a maximum activation of 102.0% relative to Gly-Sar, with an IC50 of 110000.0 nM. Moreover, Guacetisal demonstrates biological activity against Angiotensin I converting enzyme, with an IC50 value of 457088.19 nM. Additionally, it binds to the human peptide transporter PepT2 in SKTP cells, exhibiting Ki values of 4400.0 nM and 4365.16 nM in different assays, indicating a moderate binding affinity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Guacetisal is extracted from the esterification reaction of acetylsalicylic acid with guaiacol which can be used for research on the treatment of chronic bronchitis.

Chemical Properties

Molecular Weight	286.28
Formula	C₁₆H₁₄O₅
Cas No.	55482-89-8
Smiles	O=C(OC=1C=CC=CC1OC)C=2C=CC=CC2OC(=O)C
Relative Density.	1.220 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (331.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4931 mL	17.4654 mL	34.9308 mL	174.6542 mL
5 mM	0.6986 mL	3.4931 mL	6.9862 mL	34.9308 mL
10 mM	0.3493 mL	1.7465 mL	3.4931 mL	17.4654 mL
20 mM	0.1747 mL	0.8733 mL	1.7465 mL	8.7327 mL
50 mM	0.0699 mL	0.3493 mL	0.6986 mL	3.4931 mL
100 mM	0.0349 mL	0.1747 mL	0.3493 mL	1.7465 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc