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SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated

Catalog No. TMPY-05547
Synonyms: CS1, SLAM7, CD319, SLAM family member 7, CRACC, 19A

SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5.

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SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated
Pack Size Availability Price/USD Quantity
20 μg 5 days $ 306.00
100 μg 5 days $ 726.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5.
Species Human
Expression System HEK293 Cells
Tag C-hFc
Accession Number Q9NQ25-5
Synonyms CS1, SLAM7, CD319, SLAM family member 7, CRACC, 19A
Construction The Human SLAMF7 (NP_001269521.1) (Met1-Met226) was expressed with the Fc region of Human IgG1 at the C-terminus. The purified protein was biotinylated in vitro.
Protein Purity > 85 % as determined by SDS-PAGE
Molecular Weight 49.1 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.

References and Literature

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Keywords

SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated CS 1 CS1 CD-319 SLAM7 CD319 SLAM-7 SLAM family member 7 CD 319 CS-1 CRACC 19A SLAM 7 recombinant recombinant-proteins proteins protein

 

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