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Parsatuzumab (Synonyms: RO-5490248, RG 7414, MEGF-0444A, MEGF0444A, M0444A, Anti-EGFL7)
Catalog No. T76756 Copy Product Info
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Parsatuzumab (RG 7414) is a humanized monoclonal antibody targeting EGFL7, which is also used as an immunomodulator.Parsatuzumab selectively inhibits the interaction between EGFL7 and endothelial cells, and has an inhibitory effect on endothelial growth factor (VEGF).Parsatuzumab has been used in combination with other compounds for a long time. Combined use to study rectal cancer
Parsatuzumab
Copy Product Info🥰Excellent
Catalog No. T76756
Synonyms RO-5490248, RG 7414, MEGF-0444A, MEGF0444A, M0444A, Anti-EGFL7
Parsatuzumab (RG 7414) is a humanized monoclonal antibody targeting EGFL7, which is also used as an immunomodulator.Parsatuzumab selectively inhibits the interaction between EGFL7 and endothelial cells, and has an inhibitory effect on endothelial growth factor (VEGF).Parsatuzumab has been used in combination with other compounds for a long time. Combined use to study rectal cancer
Cas No. 1312797-14-0
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $157 | In Stock | In Stock | |
| 5 mg | $413 | - | In Stock | |
| 10 mg | $662 | - | In Stock | |
| 25 mg | $987 | - | In Stock | |
| 50 mg | $1,370 | - | In Stock | |
| 100 mg | $1,850 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:> 95%
Appearance:Liquid
Color:Transparent
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| Description | Parsatuzumab (RG 7414) is a humanized monoclonal antibody targeting EGFL7, which is also used as an immunomodulator.Parsatuzumab selectively inhibits the interaction between EGFL7 and endothelial cells, and has an inhibitory effect on endothelial growth factor (VEGF).Parsatuzumab has been used in combination with other compounds for a long time. Combined use to study rectal cancer |
| In vitro | EGFL7, a vascular-restricted extracellular matrix protein, promotes endothelial cell adhesion and survival[2]. Parsatuzumab inhibits cell proliferation and induces apoptosis in patient-derived xenograft (PDX) cells after 48 hours[1]. |
| In vivo | In several xenograft and genetically engineered murine tumor models, Parsatuzumab (anti-EGFL7) enhances the antiangiogenesis, tumor growth control, and survival associated with antiVEGF monotherapy[1].In mouse models of mantle cell lymphoma (MCL), Parsatuzumab (50 mg/kg; i.v.; 3 times per week) targets EGFL7, inhibits MCL cell growth, and prolongs survival[1]. |
| Synonyms | RO-5490248, RG 7414, MEGF-0444A, MEGF0444A, M0444A, Anti-EGFL7 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | EGFL7 |
| Molecular Weight | 148.22 kDa |
| Cas No. | 1312797-14-0 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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