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Parsatuzumab
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Catalog No. T76756Cas No. 1312797-14-0
Alias RO-5490248, RG 7414, MEGF-0444A, MEGF0444A, M0444A, Anti-EGFL7
Parsatuzumab (RG 7414) is a humanized monoclonal antibody targeting EGFL7, which is also used as an immunomodulator.Parsatuzumab selectively inhibits the interaction between EGFL7 and endothelial cells, and has an inhibitory effect on endothelial growth factor (VEGF).Parsatuzumab has been used in combination with other compounds for a long time. Combined use to study rectal cancer
Parsatuzumab
😃Good
Catalog No. T76756Alias RO-5490248, RG 7414, MEGF-0444A, MEGF0444A, M0444A, Anti-EGFL7Cas No. 1312797-14-0
Parsatuzumab (RG 7414) is a humanized monoclonal antibody targeting EGFL7, which is also used as an immunomodulator.Parsatuzumab selectively inhibits the interaction between EGFL7 and endothelial cells, and has an inhibitory effect on endothelial growth factor (VEGF).Parsatuzumab has been used in combination with other compounds for a long time. Combined use to study rectal cancer
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $157 | In Stock | In Stock | |
| 5 mg | $413 | - | In Stock | |
| 10 mg | $662 | - | In Stock | |
| 25 mg | $987 | - | In Stock | |
| 50 mg | $1,370 | - | In Stock | |
| 100 mg | $1,850 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Parsatuzumab (RG 7414) is a humanized monoclonal antibody targeting EGFL7, which is also used as an immunomodulator.Parsatuzumab selectively inhibits the interaction between EGFL7 and endothelial cells, and has an inhibitory effect on endothelial growth factor (VEGF).Parsatuzumab has been used in combination with other compounds for a long time. Combined use to study rectal cancer |
| In vitro | EGFL7, a vascular-restricted extracellular matrix protein, promotes endothelial cell adhesion and survival[2]. Parsatuzumab inhibits cell proliferation and induces apoptosis in patient-derived xenograft (PDX) cells after 48 hours[1]. |
| In vivo | In several xenograft and genetically engineered murine tumor models, Parsatuzumab (anti-EGFL7) enhances the antiangiogenesis, tumor growth control, and survival associated with antiVEGF monotherapy[1].In mouse models of mantle cell lymphoma (MCL), Parsatuzumab (50 mg/kg; i.v.; 3 times per week) targets EGFL7, inhibits MCL cell growth, and prolongs survival[1]. |
| Synonyms | RO-5490248, RG 7414, MEGF-0444A, MEGF0444A, M0444A, Anti-EGFL7 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | EGFL7 |
| Molecular Weight | 148.22 kDa |
| Cas No. | 1312797-14-0 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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