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MMV688845 (Synonyms: (R)-GSK1729177A)

Name: MMV688845
Brand: TargetMol
SKU: T73271
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T73271 Copy Product Info

Purity: 99.98%

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MMV688845 is a bactericidal nontuberculous mycobacteria (NTM) RNA polymerase inhibitor that exhibits anti-tuberculosis efficacy and is effective against Mycobacterium abscessus.

MMV688845

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Catalog No. T73271

Synonyms (R)-GSK1729177A

MMV688845 is a bactericidal nontuberculous mycobacteria (NTM) RNA polymerase inhibitor that exhibits anti-tuberculosis efficacy and is effective against Mycobacterium abscessus.

Cas No. 2208962-35-8

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Pack Size	Price	USA Stock	Global Stock
1 mg	$45	-	In Stock
5 mg	$106	-	In Stock
10 mg	$179	-	In Stock
25 mg	$328	-	In Stock
50 mg	$488	-	In Stock
1 mL x 10 mM (in DMSO)	$117	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.98%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	MMV688845 is a bactericidal nontuberculous mycobacteria (NTM) RNA polymerase inhibitor that exhibits anti-tuberculosis efficacy and is effective against Mycobacterium abscessus.
In vitro	MMV688845 dose-dependently inhibits the growth of M. abscessus (ATCC 19977) with an MIC of 9.3 uM [1].
Synonyms	(R)-GSK1729177A

Chemical Properties

Molecular Weight	435.54
Formula	C₂₄H₂₅N₃O₃S
Cas No.	2208962-35-8
Smiles	N(C([C@@H](CC1=CC=CC=C1)NC(=O)C2=CC=CS2)=O)C3=C(C=CC=C3)N4CCOCC4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (459.2 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2960 mL	11.4800 mL	22.9600 mL	114.8000 mL
5 mM	0.4592 mL	2.2960 mL	4.5920 mL	22.9600 mL
10 mM	0.2296 mL	1.1480 mL	2.2960 mL	11.4800 mL
20 mM	0.1148 mL	0.5740 mL	1.1480 mL	5.7400 mL
50 mM	0.0459 mL	0.2296 mL	0.4592 mL	2.2960 mL
100 mM	0.0230 mL	0.1148 mL	0.2296 mL	1.1480 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc