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Mitoquinone mesylate (Synonyms: MitoQ10 mesylate, MitoQ mesylate)

Name: Mitoquinone mesylate
Brand: TargetMol
SKU: T12059L
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T12059L Copy Product Info

Purity: 98.36%

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Mitoquinone mesylate (MitoQ10 mesylate) is a potent TRAP1 inhibitor (IC50=0.2 μM). Mitoquinone mesylate is an antioxidant that prevents oxidative damage and targets mitochondria of TPP.

Mitoquinone mesylate

Copy Product Info

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Catalog No. T12059L

Synonyms MitoQ10 mesylate, MitoQ mesylate

Mitoquinone mesylate (MitoQ10 mesylate) is a potent TRAP1 inhibitor (IC50=0.2 μM). Mitoquinone mesylate is an antioxidant that prevents oxidative damage and targets mitochondria of TPP.

Cas No. 845959-50-4

Pack Size	Price	USA Stock	Global Stock
1 mg	$31	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$198	In Stock	In Stock
50 mg	$297	-	In Stock
100 mg	$455	-	In Stock
1 mL x 10 mM (in DMSO)	$109	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.36%

Appearance:Oil

Color:Red

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Mitoquinone mesylate (MitoQ10 mesylate) is a potent TRAP1 inhibitor (IC50=0.2 μM). Mitoquinone mesylate is an antioxidant that prevents oxidative damage and targets mitochondria of TPP.
Targets&IC50	MHV-A59:0.310 μM, SARS-CoV-2 Delta variant:1.6 μM
In vitro	METHODS: MDA-MB-231 (breast cancer cells), MDA-MB-231BR (brain metastatic breast cancer cells), and U87MG (glioma cells) were treated with Mitoquinone mesylate and cell proliferation was monitored using a live cell imaging system. RESULTS: Mitoquinone mesylate inhibited cell proliferation (IC50=0.38 μM). [1]
In vivo	METHODS: To investigate the role of Mitoquinone mesylate in acute pancreatitis in mice, mice were treated with Mitoquinone mesylate (10 mg/kg). RESULTS: Treatment with Mitoquinone mesylate significantly reduced pancreatic edema and neutrophil infiltration. Mitoquinone mesylate increased serum amylase in a dose-dependent manner, approximately doubling at higher doses. Mitoquinone mesylate treatment nearly doubled caerulein-induced lung MPO activity at a dose of 10 mg/kg, and serum IL-6 levels were also significantly increased. [2]
Synonyms	MitoQ10 mesylate, MitoQ mesylate

Chemical Properties

Molecular Weight	678.81
Formula	C₃₈H₄₇O₇PS
Cas No.	845959-50-4
Smiles	[O-]S(=O)(C)=O.O=C(C(CCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=C4C)C(OC)=C(OC)C4=O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (353.56 mM), Sonication is recommended.

H2O: 10 mg/mL (14.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (7.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4732 mL	7.3658 mL	14.7317 mL	73.6583 mL
5 mM	0.2946 mL	1.4732 mL	2.9463 mL	14.7317 mL
10 mM	0.1473 mL	0.7366 mL	1.4732 mL	7.3658 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0737 mL	0.3683 mL	0.7366 mL	3.6829 mL
50 mM	0.0295 mL	0.1473 mL	0.2946 mL	1.4732 mL
100 mM	0.0147 mL	0.0737 mL	0.1473 mL	0.7366 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc