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Mitoquinone mesylate

Name: Mitoquinone mesylate
Brand: TargetMol
SKU: T12059L
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12059LCas No. 845959-50-4

Alias MitoQ10 mesylate, MitoQ mesylate

Mitoquinone mesylate (MitoQ10 mesylate) is a potent TRAP1 inhibitor (IC50=0.2 μM). Mitoquinone mesylate is an antioxidant that prevents oxidative damage and targets mitochondria of TPP.

Mitoquinone mesylate

🥰Excellent

Purity: 98.36%

Catalog No. T12059LAlias MitoQ10 mesylate, MitoQ mesylateCas No. 845959-50-4

Mitoquinone mesylate (MitoQ10 mesylate) is a potent TRAP1 inhibitor (IC50=0.2 μM). Mitoquinone mesylate is an antioxidant that prevents oxidative damage and targets mitochondria of TPP.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$198	In Stock	In Stock
50 mg	$297	-	In Stock
100 mg	$455	-	In Stock
1 mL x 10 mM (in DMSO)	$109	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.36%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Mitoquinone mesylate (MitoQ10 mesylate) is a potent TRAP1 inhibitor (IC50=0.2 μM). Mitoquinone mesylate is an antioxidant that prevents oxidative damage and targets mitochondria of TPP.
Targets&IC50	MHV-A59:0.310 μM, SARS-CoV-2 Delta variant:1.6 μM
In vitro	METHODS: MDA-MB-231 (breast cancer cells), MDA-MB-231BR (brain metastatic breast cancer cells), and U87MG (glioma cells) were treated with Mitoquinone mesylate and cell proliferation was monitored using a live cell imaging system. RESULTS: Mitoquinone mesylate inhibited cell proliferation (IC50=0.38 μM). [1]
In vivo	METHODS: To investigate the role of Mitoquinone mesylate in acute pancreatitis in mice, mice were treated with Mitoquinone mesylate (10 mg/kg). RESULTS: Treatment with Mitoquinone mesylate significantly reduced pancreatic edema and neutrophil infiltration. Mitoquinone mesylate increased serum amylase in a dose-dependent manner, approximately doubling at higher doses. Mitoquinone mesylate treatment nearly doubled caerulein-induced lung MPO activity at a dose of 10 mg/kg, and serum IL-6 levels were also significantly increased. [2]
Synonyms	MitoQ10 mesylate, MitoQ mesylate

Chemical Properties

Molecular Weight	678.81
Formula	C₃₈H₄₇O₇PS
Cas No.	845959-50-4
Smiles	[O-]S(=O)(C)=O.O=C(C(CCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=C4C)C(OC)=C(OC)C4=O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (353.56 mM), Sonication is recommended.

H2O: 10 mg/mL (14.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (7.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4732 mL	7.3658 mL	14.7317 mL	73.6583 mL
5 mM	0.2946 mL	1.4732 mL	2.9463 mL	14.7317 mL
10 mM	0.1473 mL	0.7366 mL	1.4732 mL	7.3658 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0737 mL	0.3683 mL	0.7366 mL	3.6829 mL
50 mM	0.0295 mL	0.1473 mL	0.2946 mL	1.4732 mL
100 mM	0.0147 mL	0.0737 mL	0.1473 mL	0.7366 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc