Shopping Cart
- Remove All
Your shopping cart is currently empty
Substance P
🥰Excellent
Catalog No. TP1087Cas No. 33507-63-0
Alias Neurokinin P
Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
Substance P
🥰Excellent
Purity: 99.51%
Catalog No. TP1087Alias Neurokinin PCas No. 33507-63-0
Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $52 | In Stock | |
| 5 mg | $118 | In Stock | |
| 10 mg | $188 | In Stock | |
| 25 mg | $400 | In Stock | |
| 50 mg | $595 | In Stock | |
| 100 mg | $849 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $313 | In Stock |
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View MoreBatch Information
Select Batch
Purity:99.51%
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
| Description | Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family. |
| In vitro | The process involves the desensitization and resensitization of neuropeptide substance P (SP) through the neurokinin 1 receptor (NK1-R), which may relate to the endocytosis and recycling of NK1-R. Both SP and NK1-R are internalized into clathrin-immunoreactive vesicles and subsequently segregated into distinct compartments. Initially, SP remains intact on the cell surface and in early endosomes but gradually degrades in perinuclear vesicles. SP triggers the clathrin-dependent internalization of NK1-R. Within acidified endosomes, the SP/NK1-R complex disassociates, leading to the degradation of SP while NK1-R is recycled back to the cell surface. This mechanism of SP-induced NK1-R internalization is observed in transfected epithelial cells[1]. |
| Synonyms | Neurokinin P |
| Molecular Weight | 1347.63 |
| Formula | C63H98N18O13S |
| Cas No. | 33507-63-0 |
| Smiles | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O |
| Relative Density. | 1.42g/cm3 |
| Color | White |
| Appearance | Solid |
| Sequence | Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 |
| Sequence Short | RPKPQQFFGLM-NH2 |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 10 mM, Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
| |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Substance P | purchase Substance P | Substance P cost | order Substance P | Substance P chemical structure | Substance P in vitro | Substance P formula | Substance P molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.