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Anti-TREM-2 Antibody (7N324)
🥰Excellent
Catalog No. TMAY-01618
Anti-TREM-2 Antibody (7N324) is a Rabbit antibody targeting TREM-2. Anti-TREM-2 Antibody (7N324) can be used in ELISA(Cap).
Anti-TREM-2 Antibody (7N324)
Anti-TREM-2 Antibody (7N324)
🥰Excellent
Catalog No. TMAY-01618
Anti-TREM-2 Antibody (7N324) is a Rabbit antibody targeting TREM-2. Anti-TREM-2 Antibody (7N324) can be used in ELISA(Cap).
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-TREM-2 Antibody (7N324) is a Rabbit antibody targeting TREM-2. Anti-TREM-2 Antibody (7N324) can be used in ELISA(Cap). |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 7N324 |
| Reactivity | Human |
| Application | ELISA(Cap) |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human TREM-2 / TREM2 (rh TREM-2 / TREM2; TMPY-01148; NP_061838.1; Met1-Ser174). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human TREM-2 / TREM2 Protein (TMPY-01148) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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