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Muraglitazar

Name: Muraglitazar
Brand: TargetMol
SKU: T21587
Price: 293 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T21587Cas No. 331741-94-7

Alias Pargluva, BMS-298585

Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα and PPARγ with EC50 of 320 nM and 110 nM respectively.

Muraglitazar

🥰Excellent

Purity: 99.17%

Catalog No. T21587Alias Pargluva, BMS-298585Cas No. 331741-94-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$293	In Stock	In Stock
5 mg	$719	In Stock	In Stock
10 mg	$987	In Stock	In Stock
25 mg	$1,490	In Stock	In Stock
50 mg	$1,980	In Stock	In Stock
100 mg	$2,750	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.17%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα and PPARγ with EC50 of 320 nM and 110 nM respectively.
Targets&IC50	PPARα:320 nM (EC50), PPARγ:0.14 μM, PPARα:0.42 μM, PPARγ:110 nM (EC50), PPARα (HEK293 cells):1.41 μM (EC50), PPARγ (HEK293 cells):0.04 μM (EC50)
Synonyms	Pargluva, BMS-298585

Chemical Properties

Molecular Weight	516.54
Formula	C₂₉H₂₈N₂O₇
Cas No.	331741-94-7
Smiles	C(COC1=CC=C(CN(C(OC2=CC=C(OC)C=C2)=O)CC(O)=O)C=C1)C=3N=C(OC3C)C4=CC=CC=C4
Relative Density.	1.274g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 128.8 mg/mL (249.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (6.39 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9360 mL	9.6798 mL	19.3596 mL	96.7979 mL
5 mM	0.3872 mL	1.9360 mL	3.8719 mL	19.3596 mL
10 mM	0.1936 mL	0.9680 mL	1.9360 mL	9.6798 mL
20 mM	0.0968 mL	0.4840 mL	0.9680 mL	4.8399 mL
50 mM	0.0387 mL	0.1936 mL	0.3872 mL	1.9360 mL
100 mM	0.0194 mL	0.0968 mL	0.1936 mL	0.9680 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc