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ODN 1668
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Catalog No. T74903Cas No. 1186063-66-0
Alias ODN1668
ODN 1668 is an immunostimulatory class B CpG oligodeoxynucleotide (ODN) containing an intact thio backbone of one or more CpG dinucleotides, which is primarily used as an agonist for Toll-like receptor 9 (TLR9), and also upregulates the level of IgM and induces an antimicrobial immune response via a CaTLR9-dependent pathway.
ODN 1668
ODN 1668
😃Good
Catalog No. T74903Alias ODN1668Cas No. 1186063-66-0
ODN 1668 is an immunostimulatory class B CpG oligodeoxynucleotide (ODN) containing an intact thio backbone of one or more CpG dinucleotides, which is primarily used as an agonist for Toll-like receptor 9 (TLR9), and also upregulates the level of IgM and induces an antimicrobial immune response via a CaTLR9-dependent pathway.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $123 | - | In Stock | |
| 5 mg | $269 | In Stock | In Stock | |
| 10 mg | $419 | - | In Stock | |
| 25 mg | $687 | - | In Stock | |
| 50 mg | $955 | - | In Stock | |
| 100 mg | $1,280 | - | In Stock | |
| 200 mg | $1,730 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Appearance:Viscous
Color:Yellow
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Storage & Solubility Information
| Description | ODN 1668 is an immunostimulatory class B CpG oligodeoxynucleotide (ODN) containing an intact thio backbone of one or more CpG dinucleotides, which is primarily used as an agonist for Toll-like receptor 9 (TLR9), and also upregulates the level of IgM and induces an antimicrobial immune response via a CaTLR9-dependent pathway. |
| In vitro | Treatment of mouse bone marrow-derived macrophages with ODN 1668 (6-60 µg/mL, 12-72 hours) increased the production of S100A8/A9, IL-6, and β-galactosidase. [1] Treatment of anti-CD3-treated CD8+ T cells with ODN 1668 (0.3-3.0 μM, 4 days) promoted cell growth in a dose-dependent manner. [2] Treatment of head kidney lymphocytes with ODN 1668 (0.25-32 μg/mL, 12 hours) promoted the proliferation of head kidney lymphocytes and enhanced the expression of immune genes. [3] |
| In vivo | Treatment of male Wistar rats (175-200 g) with ODN 1668 (1, 5 mg/kg, intraperitoneal and subcutaneous) induced moderate fever and anorexia, and induced a significant increase in IL-6.[4] |
| Synonyms | ODN1668 |
| Molecular Weight | 6364.1 |
| Cas No. | 1186063-66-0 |
| Storage | store under nitrogen,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | H2O: 20 mg/mL (3.14 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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