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Nitrosoglutathione

Name: Nitrosoglutathione
Brand: TargetMol
SKU: T19930
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19930Cas No. 57564-91-7

Alias SNOG, S-Nitrosoglutathione, GSNO, Glutathione thionitrite

Nitrosoglutathione (GSNO) is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses.

Nitrosoglutathione

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Purity: 99.68%

Catalog No. T19930Alias SNOG, S-Nitrosoglutathione, GSNO, Glutathione thionitriteCas No. 57564-91-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$48	In Stock	In Stock
10 mg	$67	In Stock	In Stock
25 mg	$107	In Stock	In Stock
50 mg	$156	In Stock	In Stock
100 mg	$229	-	In Stock
500 mg	$572	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.68%

Appearance:Solid

Color:Pink to Red

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Product Introduction

Bioactivity

Description	Nitrosoglutathione (GSNO) is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses.
In vitro	GSNO completely abolished the AngII-dependent AT1 receptor-mediated vasoconstriction of cerebral arteries. GSNO had no impact on responses to other vasoconstrictors sharing (phenylephrine, U46619) or not (5-HT) the same signalling pathway[1].
In vivo	Elevated blood pressure, proteinuria, and intrauterine growth restriction associated with PE were induced in Sprague-Dawley rats using L-NAME. These were partially reversed with the use of GSNO[3].
Synonyms	SNOG, S-Nitrosoglutathione, GSNO, Glutathione thionitrite

Chemical Properties

Molecular Weight	336.32
Formula	C₁₀H₁₆N₄O₇S
Cas No.	57564-91-7
Smiles	N[C@@H](CCC(=O)N[C@@H](CSN=O)C(=O)NCC(O)=O)C(O)=O
Relative Density.	1.68 g/cm3
Sequence	H-gGlu-Cys(NO)(NO)-Gly-OH
Sequence Short	XXG

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.67 mg/mL (49.57 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: 12.5 mg/mL (37.17 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9734 mL	14.8668 mL	29.7336 mL	148.6679 mL
5 mM	0.5947 mL	2.9734 mL	5.9467 mL	29.7336 mL
10 mM	0.2973 mL	1.4867 mL	2.9734 mL	14.8668 mL
20 mM	0.1487 mL	0.7433 mL	1.4867 mL	7.4334 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc