Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

Lipoxin A4

Copy Product Info
😃Good
Catalog No. T36051Cas No. 89663-86-5
Alias LXA4

Lipoxin A4 (LXA4) is a lipoxygenase-derived arachidonate-like mediator with anti-inflammatory properties.Lipoxin A4 attenuates MSU crystal-induced NLRP3 inflammasome activation through inhibition of Nrf2, and regulates M1/M2 macrophage polarization through the FPR2-IRF pathway.Lipoxin inhibits oxidative stress and inflammation.

Lipoxin A4
Other Forms of Lipoxin A4:

Lipoxin A4

Copy Product Info
😃Good
Purity: 95%
Catalog No. T36051Alias LXA4Cas No. 89663-86-5
Lipoxin A4 (LXA4) is a lipoxygenase-derived arachidonate-like mediator with anti-inflammatory properties.Lipoxin A4 attenuates MSU crystal-induced NLRP3 inflammasome activation through inhibition of Nrf2, and regulates M1/M2 macrophage polarization through the FPR2-IRF pathway.Lipoxin inhibits oxidative stress and inflammation.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μg (283.71 µM * 250 μL in Ethanol)$899-In Stock
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Batch Information

Select Batch
Purity:95%
Appearance:Liquid
Color:Transparent
Contact us for more batch information

Resource Download

COA

Product Introduction

Bioactivity
Description
Lipoxin A4 (LXA4) is a lipoxygenase-derived arachidonate-like mediator with anti-inflammatory properties.Lipoxin A4 attenuates MSU crystal-induced NLRP3 inflammasome activation through inhibition of Nrf2, and regulates M1/M2 macrophage polarization through the FPR2-IRF pathway.Lipoxin inhibits oxidative stress and inflammation.
In vitro
Lipoxin A4 (LXA4; NHEKs) inhibits the expression of IL-6 and IL-8, downregulates the expression of cyclin D1, and suppresses the ERK1/2 phosphorylation and NF-kB-p65 nuclear translocation in NHEKs.[2]
Lipoxin A4 (100 nM; preincubation for 30 minutes; NHEKs) inhibits the NHEKs proliferation with or without stimulating by LPS (10 μg/mL).[2]
Lipoxin A4 (100  nM; preincubation for 30 minutes) downregulates the LPS-induced secretion and expression of HMGB1 in keratinocytes.[1]
SynonymsLXA4
Chemical Properties
Molecular Weight352.47
FormulaC20H32O5
Cas No.89663-86-5
Smiles[C@H]([C@H](CCCC(O)=O)O)(/C=C/C=C/C=C\C=C\[C@H](CCCCC)O)O
Storage & Solubility Information
Storagestore at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
PBS (pH 7.2): 0.05 mg/mL (0.14 mM), Sonication is recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble.)
Ethanol: 30 mg/mL (85.11 mM), Sonication is recommended.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

LXA-4LXA 4Lipoxin A-4Lipoxin A4Interleukin RelatedEndogenousMetaboliteEndogenous Metabolite
Related Tags: buy Lipoxin A4 | purchase Lipoxin A4 | Lipoxin A4 cost | order Lipoxin A4 | Lipoxin A4 chemical structure | Lipoxin A4 in vitro | Lipoxin A4 formula | Lipoxin A4 molecular weight
TargetMol | Logo

Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.