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Anti-Phospho-Tuberin (Thr1462) Polyclonal Antibody 2
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Catalog No. TMAB-11403
Anti-Phospho-Tuberin (Thr1462) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Tuberin (Thr1462). Anti-Phospho-Tuberin (Thr1462) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF,FCM.
Anti-Phospho-Tuberin (Thr1462) Polyclonal Antibody 2
Anti-Phospho-Tuberin (Thr1462) Polyclonal Antibody 2
😃Good
Catalog No. TMAB-11403
Anti-Phospho-Tuberin (Thr1462) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Tuberin (Thr1462). Anti-Phospho-Tuberin (Thr1462) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-Tuberin (Thr1462) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Tuberin (Thr1462). Anti-Phospho-Tuberin (Thr1462) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF,FCM. |
| Ig Type | IgG |
| Reactivity | Human,Rat (predicted:Mouse,Chicken,Dog,Pig,Cow,Horse,Rabbit) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 2μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes. |
| Tissue Specificity | Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human Tuberin around the phosphorylation site of Thr1462 |
| Antigen Species | Human |
| Gene Name | TSC2 |
| Gene ID | |
| Protein Name | Tuberin |
| Uniprot ID | |
| Function | In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. |
| Molecular Weight | Theoretical: 200 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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