Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis. It exhibits its efficacy in targeting ROCK2 enzymes within HaCaT cells and has demonstrated beneficial effects in a psoriasis-like mouse model.
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Description | ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis. It exhibits its efficacy in targeting ROCK2 enzymes within HaCaT cells and has demonstrated beneficial effects in a psoriasis-like mouse model. |
In vitro | ROCK2-IN-7 (2-5$, 24 hours) inhibits the ROCK2/pSTAT3 signaling pathway in HaCaT cells [1]. |
In vivo | ROCK2-IN-7 administration (20-80 mg/kg, oral, daily for 7 days) reduced key interleukins associated with the IL-23/Th17 axis and important factors involved in keratinocyte proliferation [1]. Concurrently, ROCK2-IN-79 (20-80 mg/kg, oral, daily for 7 days) inhibited systemic immune activation, alleviating inflammation [1]. |
Molecular Weight | 445.53 |
Formula | C26H28FN5O |
CAS No. | 3000541-95-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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ROCK2-IN-7 3000541-95-4 Cell Cycle/Checkpoint Cytoskeletal Signaling Stem Cells ROCK inhibitor inhibit