Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DB2313 (Carboximidamide) is a potent transcription factor PU.1 inhibitor, IC50=14 nM. DB2313 disrupts the interaction of PU.1 with target gene promoters. DB2313 induces apoptosis of acute myeloid leukemia (AML) cells, and has anticancer effects
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 50.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 455.00 | |
50 mg | In stock | $ 672.00 |
Description | DB2313 (Carboximidamide) is a potent transcription factor PU.1 inhibitor, IC50=14 nM. DB2313 disrupts the interaction of PU.1 with target gene promoters. DB2313 induces apoptosis of acute myeloid leukemia (AML) cells, and has anticancer effects |
In vitro | DB2313 reduces PU.1 binding to the promoters of E2f1, Junb, and Csf1r in acute myeloid leukemia (AML) cells, significantly impairing their proliferation, particularly in PU.1 URE–/– AML cells where it shows an IC50 of 7.1 μM with minimal impact on normal hematopoietic cells at comparable doses. This treatment also increases apoptosis by 3.5 times in PU.1 URE–/– AML murine cells and notably diminishes their clonogenic survival across successive replatings, culminating in a total loss of clonogenic capacity from the fourth replating onwards[1]. |
In vivo | DB2313 (17 mg/kg; i.p.; three times per week for 3 weeks) treatment decreases leukemia progression and results in increased survival in mice. |
Synonyms | Carboximidamide |
Molecular Weight | 708.83 |
Formula | C42H41FN8O2 |
CAS No. | 2170606-74-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3 mg/mL (4.2 mM), Sonication and heating to 70℃ are recommended.
You can also refer to dose conversion for different animals. More
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DB2313 2170606-74-1 Apoptosis DB-2313 Carboximidamide DB 2313 inhibitor inhibit