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Ac-YVAD-AFC

🥰Excellent
Catalog No. T78431Cas No. 219137-85-6

Ac-YVAD-AFC is a fluorescent peptide substrate used to detect caspase-1. When cleaved, it releases the fluorescent molecule AFC, with an excitation wavelength of 400 nm and an emission wavelength of 505 nm.

Ac-YVAD-AFC

Ac-YVAD-AFC

🥰Excellent
Purity: 99.88%
Catalog No. T78431Cas No. 219137-85-6
Ac-YVAD-AFC is a fluorescent peptide substrate used to detect caspase-1. When cleaved, it releases the fluorescent molecule AFC, with an excitation wavelength of 400 nm and an emission wavelength of 505 nm.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$44-In Stock
5 mg$88In StockIn Stock
10 mg$163In StockIn Stock
25 mg$273-In Stock
50 mg$410-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.88%
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Product Introduction

Bioactivity
Description
Ac-YVAD-AFC is a fluorescent peptide substrate used to detect caspase-1. When cleaved, it releases the fluorescent molecule AFC, with an excitation wavelength of 400 nm and an emission wavelength of 505 nm.
Chemical Properties
Molecular Weight719.66
FormulaC33H36F3N5O10
Cas No.219137-85-6
SmilesC(F)(F)(F)C=1C=2C(=CC(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=C(O)C=C3)NC(C)=O)=O)C(C)C)=O)C)=O)CC(O)=O)=O)=CC2)OC(=O)C1
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (111.16 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.59 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.3895 mL6.9477 mL13.8955 mL69.4773 mL
5 mM0.2779 mL1.3895 mL2.7791 mL13.8955 mL
10 mM0.1390 mL0.6948 mL1.3895 mL6.9477 mL
20 mM0.0695 mL0.3474 mL0.6948 mL3.4739 mL
50 mM0.0278 mL0.1390 mL0.2779 mL1.3895 mL
100 mM0.0139 mL0.0695 mL0.1390 mL0.6948 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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