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ZXH-1-161 TFA

Name: ZXH-1-161 TFA
Brand: TargetMol
SKU: T63010L
Rating: 4.5 (1 reviews)

(Synonyms: ZXH-1-161 TFA (2407654-51-5 free base)) Copy Product Info

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Synonyms: ZXH-1-161 TFA (2407654-51-5 free base)

Catalog No. T63010L Copy Product Info

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ZXH-1-161 TFA is a potent small molecule degrader that functions as a modulator of the Cereblon (CRBN) E3 ubiquitin ligase and targets the degradation of the GSPT1 protein, demonstrating anti-tumor potential in multiple myeloma (MM1.S cell line) research. ZXH-1-161 TFA inhibits the STAT3 signaling pathway, effectively suppressing tumor cell proliferation and inducing apoptosis. As an important tool compound in the field of molecular glues, ZXH-1-161 is commonly used in research related to targeted protein degradation and cancer mechanisms.

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Product Introduction

Bioactivity

Description	ZXH-1-161 TFA is a potent small molecule degrader that functions as a modulator of the Cereblon (CRBN) E3 ubiquitin ligase and targets the degradation of the GSPT1 protein, demonstrating anti-tumor potential in multiple myeloma (MM1.S cell line) research. ZXH-1-161 TFA inhibits the STAT3 signaling pathway, effectively suppressing tumor cell proliferation and inducing apoptosis. As an important tool compound in the field of molecular glues, ZXH-1-161 is commonly used in research related to targeted protein degradation and cancer mechanisms.
In vitro	ZXH-1-161 TFA(0–50 µM; 48 h) exhibited CRBN-dependent antiproliferative activity in MM1.S wild-type cells, with an IC₅₀ of 0.039 µM [1]. ZXH-1-161 TFA(0.01–10 µM; 4 h) induces GSPT1 degradation in MM1.S cells [1].
Synonyms	ZXH-1-161 TFA (2407654-51-5 free base)

Chemical Properties

Molecular Weight	582.54
Formula	C₂₈H₂₅F₃N₆O₅
Smiles	O=C1NC(C(CC1)N2C(C3=C(C2)C(NC4=NC(NC5=CC=C6C(CCC6)=C5)=NC=C4)=CC=C3)=O)=O.O=C(C(F)(F)F)O

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: ZXH-1-161 TFA chemical structure | ZXH-1-161 TFA in vitro | ZXH-1-161 TFA formula | ZXH-1-161 TFA molecular weight