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Influenza Virus

Influenza, commonly known as "the flu", is an infectious disease caused by an influenza virus. Symptoms can be mild to severe. The most common symptoms include: high fever, runny nose, sore throat, muscle and joint pain, headache, coughing, and feeling tired . Three of the four types of influenza viruses affect humans: Type A, Type B, and Type C. Type D has not been known to infect humans, but is believed to have the potential to do so.

  • Vadimezan
    T6273117570-53-3
    Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without affecting blood flow in normal tissues.
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  • Curcumin
    T1516458-37-7
    Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, anti-inflammatory and antioxidant.
    • $30
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  • Molnupiravir
    T609512492423-29-5
    Molnupiravir (MK-4482) (EIDD-2801) is a prodrug of the ribonucleoside analog EIDD-1931 which is orally bioavailable. Molnupiravir can be used in COVID-19, seasonal and pandemic influenza research that has broad spectrum antiviral activity against multiple coronaviruses and influenza virus, for example, SARS-CoV-2, MERS-CoV, SARS-CoV [1][2].
    • $34
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  • Tunicamycin
    T1322911089-65-9
    Tunicamycin is a mixture of antibiotics that inhibit N-linked glycosylation by blocking GlcNAc phosphotransferase (GPT). Tunicamycin has antitumor activity, as well as anti-bacterial, anti-fungal, and anti-viral activity.
    • $105
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  • Hypericin
    T6S0923548-04-9
    1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL-mediated osteoclastogenesis via affecting ERK signalling in vitro and suppresses wear particle-induced osteolysis in vivo.
    • $52
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  • Nuezhenidic acid
    TN1073183238-67-7
    Nuezhenidic acid is a natural product, posseses inhibitory activities against influenza A virus.
    • $263
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  • Favipiravir
    T6833259793-96-9
    Favipiravir (T-705) (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.
    • $41
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  • Coumarin
    T077591-64-5
    Coumarin is a chemical compound/poison found in many plants, notably in high concentration in the tonka bean, woodruff, and bison grass. It has clinical value as the precursor for several anticoagulants, notably warfarin.
    • $33
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  • AEBSF hydrochloride
    T637030827-99-7
    AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.
    • $30
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  • Salcomine
    T2050014167-18-1
    Salcomine (NSC-32965) shows anti-influenza virus activity.
    • $50
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  • Desaminotyrosine
    T2862501-97-3
    Desaminotyrosine (3-(4-Hydroxyphenyl)propionic acid) is a microbially associated metabolite. Desaminotyrosine protects from influenza through augmentation of type I interferon signaling.
    • $42
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  • Chelidonine
    T5S0055476-32-4
    1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model compound for overcoming MDR and for enhancing cytotoxicity of chemotherapeutics, especially against leukaemia cells, its efficacy needs to be confirmed in animal models. 3. Chelidonine may be a potential therapeutic agent against metastasis of invasive human cancer cells, exhibits antimigratory and antiinvasive effects in MDA-MB-231 cells, by suppressing COL-induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent downregulation of IPP downstream signaling molecules, such as Akt and ERK1/2.
    • $96
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  • Tubercidin
    T700469-33-0
    Tubercidin (Sparsomycin A), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhibits antifungal and antiviral activities.
    • $48
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  • Glycitin
    T282040246-10-4
    Glycitin (Glycitein 7-O-β-glucoside), a natural isoflavone isolated from legumes, can promote the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover.
    • $60
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  • Sophocarpine monohydrate
    T2746145572-44-7
    Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
    • $50
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  • Umifenovir hydrochloride
    T0104131707-23-8
    Umifenovir hydrochloride (Arbidol HCl) , an broad-spectrum antiviral chemical agent, can inhibit cell invade of enveloped viruses by blocking viral fusion with host cell membrane.
    • $50
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  • Nitazoxanide
    T154655981-09-4
    Nitazoxanide (NSC-697855) is a synthetic benzamide with antiprotozoal activity. Nitazoxanide exerts its antiprotozoal activity by interfering with the pyruvate ferredoxin/flavodoxin oxidoreductase dependent electron transfer reaction.
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  • Picroside II
    T281739012-20-9
    Picroside II (Vanilloyl catalpol) is the main active ingredient in iridoid glycosides. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.
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  • Naringenin
    T2838480-41-1
    Naringenin (NSC-11855) is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate metabolism promoter, immunity system modulater. This substance has also been shown to repair DNA.
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  • Baloxavir marboxil
    T61951985606-14-1
    Baloxavir marboxil (S-033188) is a novel cap-dependent endonuclease inhibitor for the treatment of influenza A and B virus infections.
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  • Arctigenin
    T29577770-78-7
    (-)-Arctigenin ((-)-Arctigenin) is found in burdock. (-)-Arctigenin is isolated from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD). Arctigenin is a lignan found in certain plants of the Asteraceae, including the Greater burdock (Arctium lappa) and Saussurea heteromalla. It has shown antiviral and anticancer effects. It is the aglycone of arctiin.
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  • α-Vitamin E
    T164859-02-9
    α-Vitamin E (Dexrabeprazole Sodium) is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
    • $38
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  • Isoliquiritigenin
    T0725961-29-5
    Isoliquiritigenin (ISL), an anti-tumor flavonoid from the root of Glycyrrhiza glabra, suppresses aldose reductase (IC50=320 nM).
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  • Ginsenoside Rb2
    T391911021-13-9
    Ginsenoside Rb2 (Ginsenoside C) found in species of Panax, upregulating GPR120 gene expression.
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  • Octyl gallate
    T2S18651034-01-1
    1. Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive. 2. Octyl Gallate has antimetastatic activity. 3. Octyl Gallate shows antimicrobial activity against H. pylori, with a minimum inhibitory concentration (MIC) value of 125 ug/mL. 4. Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease.5. Octyl Gallate is a potential anticancer agent, it exhibited decreased MCF-7 & MDA-MB-231 survival and induced apoptosis, with IC50 value of 40 uM. 6. Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) has antiviral activity, it shows an inhibitory effect on the growth of herpes simplex virus type 1 (HSV-1) in HEp-2 or Vero cells. 7. Octyl gallate shows antifungal activity against Saccharomyces cerevisiae ATCC7754 and Zygosaccharomyces bailii ATCC 60483.
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  • Oseltamivir
    T5186L196618-13-0
    Oseltamivir (GS 4104) is an orally active and highly potent viral neuraminidase (NA) with antiviral activity, inhibits A/H3N2, A/H1N2, A/H1N1 and influenza B viruses, and can be used in studies of influenza and pneumonia.
    • $31
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  • Camptothecin
    T11237689-03-4
    Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis.
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  • Camphor
    T295276-22-2
    Camphor (2-Camphanone) is a bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent.
    • $29
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  • IHVR-17028
    T388941428247-78-2In house
    IHVR-17028 is a potent broad-spectrum ERα-glucosidase I (α-glucosidase? I) inhibitor with IC50 of 0.24 μM and antiviral activity. IHVR-17028 inhibited BVDV, TCRV and DENV, and EC50 values were 0.4 μM, 0.26 μM and 0.3 μM, respectively. IHVR-17028 can be used to study infectious diseases.
    • $350
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  • Anti-Influenza agent 4
    T72037522625-85-0In house
    Anti-Influenza agent 4 is a potent and selective inhibitor of influenza virus, inhibiting A/Parma and A/Roma strains with EC50s of 62 nM and 150 nM, respectively.
    • $55
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  • CEF3 acetate(199727-62-3 free base)
    TP1782L
    CEF3 acetate corresponds to aa 13-21 of the influenza A virus M1 protein. The matrix (M1) protein of influenza A virus is a multifunctional protein that plays essential structural and functional roles in the virus life cycle.
    • $127
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  • 3-​Phenyl-​N-​[1-​(phenylmethyl)​-​4-​piperidinyl]​-tricyclo[3.3.1.13,​7]​decane-​1-​carboxamide
    T85011252187-41-9
    3- Phenyl- N- [1- (phenylmethyl) - 4- piperidinyl] -tricyclo[3.3.1.13, 7] decane- 1- carboxamide with antiviral activity against Ebola virus that targets the surface-exposed glycoprotein and inhibits viral entry into host cells. In vitro studies in Vero cells revealed the compound inhibits the viral replication with EC50 of 0.38 μM.
    • $133
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  • PP7
    T12526433238-84-7
    PP7 is a potent inhibitor of PB1-PB2 interaction(IC50 of 8.6 μM).
    • $148
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  • CEF6 acetate(913545-15-0 free base)
    TP1822L
    CEF6 acetate is a HLA-B7 restricted influenza virus nucleoprotein epitope, belongs to the CEF control peptides. The CEF control peptides are 8-12 amino acids in length, with sequences derived from the human cytomegalovirus, Epstein-Barr virus and influenz
    • $56
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  • Cletoquine hydrochloride
    T10835L1159358-29-9In house
    Cletoquine hydrochloride is a major active metabolite of Hydroxychloroquine. Cletoquine hydrochloride is a Chloroquine derivative and exhibits the ability to against the chikungunya virus (CHIKV). Cletoquine hydrochloride exhibits antimalarial effects.
    • $197
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  • NS1-IN-1
    T61831181373-35-3In house
    NS1-IN-1 is a potent NS1 inhibitor.NS1-IN-1 displays antiviral activity by inhibiting mTORC1 activity in a TSC1-TSC2-dependent manner.NS1-IN-1 reduces the level of viral proteins and contributes to the reduction of viral replication.
    • $350
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  • BMY-27709
    T2687399390-76-8In house
    BMY-27709 is an influenza virus growth inhibitor with an IC50 value of 3-8 μM against A/WSN/33 virus growth, and also exhibits inhibitory activity against some subtypes of influenza viruses.BMY-27709 acts early in the course of H1 and H2 virus infections, and exhibits antiviral activity through inhibition of hemagglutinin proteins. However, BMY-27709 has no effect on H3 subtype viruses and influenza B/Lee/40 viruses.
    • $350
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  • 5-Aminouridine
    T135112149-76-0
    5-Aminouridine (4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)) modifies nucleobases and is incorporated into the target DNA. 5-Aminouridine inhibits the growth of tumors, viruses, and fungi.
    • $50
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  • N-(1-benzyl-4-piperidyl)adamantane-1-carboxamide
    T8502314030-54-1
    N-(1-benzyl-4-piperidyl)adamantane-1-carboxamide inhibiting the entry of Ebola virus in host cells by binding to the surface glycoprotein, the compound inhibited the Ebola virus with EC50 of 3.9 μM.
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  • 2-PADQZ hydrochloride
    T19849L84050-22-6
    2-PADQZ hydrochloride shows antiviral activity and targets influenza A virus RNA promoter.
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  • EBOV-IN-1
    T806401335113-30-8In house
    EBOV-IN-1 is an adamantane dipeptide piperazine inhibitor against Ebola virus (EBOV) that inhibits EBOV infection and suppresses pseudotypic EBOV infection.
    • $413
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  • Trifluoromethyl-tubercidin
    T677531854086-05-7In house
    Trifluoromethyl-tubercidin (TFMT) inhibits host MTr1 and suppresses virus replication. TFMT inhibits MTr1 through interaction at its S-adenosyl-l-methionine binding pocket to restrict influenza virus replication. TFMT was effective in inhibiting viral replication in mice, displayed little toxicity.
    • $329
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  • Cephaeline hydrochloride
    T3S18523738-70-3
    Cephaeline hydrochloride, a phenolic alkaloid found in Indian Ipecac, effectively inhibits the infection of viruses ZIKV and EBOV.
    • $98
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  • Amitivir
    T26619111393-84-1
    Amitivir (LY 217896) is an inosine monophosphate dehydrogenase inhibitor. Amitivir inhibits the replication of dividing MDCK cells. Amitivir was associated with asymptomatic rises in serum uric acid levels and was ineffective in modifying the virologic or clinical course of experimental influenza A (H1N1) virus infection.
    • $133
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  • Catechin
    T0822154-23-4
    Catechin (Cianidanol) is a flavan-3-ol, a type of natural phenol and antioxidant.
    • $50
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  • Epigoitrin
    T5S00921072-93-1
    1. Epigoitrin (Goitrin) has anti-virus activity. 2. Epigoitrin has anti-oxidant activity. 3. Epigoitrin has anti-inflammation activity.
    • $31
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  • Germacrone
    T29456902-91-6
    Germacrone, a major active component found in Curcuma zedoaria oil product, shows anti-inflammatory, antiandrogenic, and antivirus activities. It also inhibits the proliferation of glioma cells by promoting apoptosis.
    • $41
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  • Oseltamivir phosphate
    T1486204255-11-8
    Oseltamivir phosphate (GS 4104) is the phosphate salt of oseltamivir, a synthetic derivative prodrug of ethyl ester with antiviral activity. By blocking neuraminidases on the surfaces of influenza viruses, oseltamivir interferes with host cell release of complete viral particles.
    • $36
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  • Rifampicin
    T068113292-46-1
    Rifampicin (Rifamycin AMP) is an antibacterial drug of the class of rifamycin.
    • $45
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  • Baicalein
    T2858491-67-8
    Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor.
    • $33
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