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SM-1295

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Catalog No. T36317Cas No. 1562375-46-5

SM-1295 serves as an antagonist to the inhibitor of apoptosis protein (IAP), demonstrating dissociation constant (Kd) values of 3077 nM for XIAP-BIR3, 3.2 nM for c-IAP1-BIR3, and 9.5 nM for c-IAP2-BIR3, respectively[1][2].

SM-1295

SM-1295

😃Good
Catalog No. T36317Cas No. 1562375-46-5
SM-1295 serves as an antagonist to the inhibitor of apoptosis protein (IAP), demonstrating dissociation constant (Kd) values of 3077 nM for XIAP-BIR3, 3.2 nM for c-IAP1-BIR3, and 9.5 nM for c-IAP2-BIR3, respectively[1][2].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,9708-10 weeks8-10 weeks
50 mg$2,5808-10 weeks8-10 weeks
100 mg$3,4008-10 weeks8-10 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
SM-1295 serves as an antagonist to the inhibitor of apoptosis protein (IAP), demonstrating dissociation constant (Kd) values of 3077 nM for XIAP-BIR3, 3.2 nM for c-IAP1-BIR3, and 9.5 nM for c-IAP2-BIR3, respectively[1][2].
Targets&IC50
XIAP BIR3:3077 nM (Kd), CIAP1-BIR3:3.2 nM (Kd), CIAP2-BIR3:9.5 nM (Kd)
In vitro
SM-1295 (compound 5) binds to both cIAP1 and cIAP2 proteins, displaying a 900-fold higher affinity for cIAP1 over XIAP[1]. It exhibits an IC50 of 46 nM in MDA-MB-231[1].
Chemical Properties
Molecular Weight598.53
FormulaC29H36BrN5O4
Cas No.1562375-46-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

SM 1295SM-1295SM1295
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