Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VEGFR2-IN-1 is a selective and potent VEGFR2 inhibitor with antitumor activity that inhibits cell proliferation and migration and can be used in the study of breast cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 293.00 | |
5 mg | In stock | $ 722.00 | |
10 mg | In stock | $ 987.00 | |
25 mg | In stock | $ 1,520.00 | |
50 mg | In stock | $ 1,980.00 | |
100 mg | In stock | $ 2,500.00 |
Description | VEGFR2-IN-1 is a selective and potent VEGFR2 inhibitor with antitumor activity that inhibits cell proliferation and migration and can be used in the study of breast cancer. |
Targets&IC50 | MCF - 10A:24.76 μM, VEGFR2:19.8 nM, MCF-7 cells:1.18 μM, 1.18 μM:MDA - MB - 231 |
In vitro | VEGFR2-IN-1 ( 0.1,1,10,100μM ; 48 h ) were effective selective inhibitors of Mcf-7, Mda-Mb-231 and Mcf-10A : MCF-7 ( IC50 = 1.18 μM ), MDA-MB-231 ( IC50 = 10.49 μM ), MCF-10A ( IC50 = 24.76 μM )[1]. |
In vivo | In Male Swiss albino mice, 21-28 g ( Xenograft model ),VEGFR2-IN-1 ( 4.2 mg/kg; i.p.; once a days ; 7 days ) Showed anticancer activity by having a tumor inhibition ratio of 54.2 % [1]. |
Molecular Weight | 398.48 |
Formula | C22H18N6S |
CAS No. | 2765224-55-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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VEGFR2-IN-1 2765224-55-1 Angiogenesis Tyrosine Kinase/Adaptors VEGFR inhibitor inhibit