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PIM1-IN-1

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Catalog No. T12474Cas No. 1417630-95-5

PIM1-IN-1 is a potent and highly selective PIM kinase inhibitor with strong preference for PIM1 and PIM3 over PIM2, effectively inhibiting BAD phosphorylation without detectable effects on FLT3 or hERG binding, and exhibiting antiproliferative and anticancer activity suitable for mechanistic studies of PIM-driven oncogenic signaling.

PIM1-IN-1

PIM1-IN-1

😃Good
Purity: 98.59%
Catalog No. T12474Cas No. 1417630-95-5
PIM1-IN-1 is a potent and highly selective PIM kinase inhibitor with strong preference for PIM1 and PIM3 over PIM2, effectively inhibiting BAD phosphorylation without detectable effects on FLT3 or hERG binding, and exhibiting antiproliferative and anticancer activity suitable for mechanistic studies of PIM-driven oncogenic signaling.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$126-In Stock
5 mg$313-In Stock
10 mg$496-In Stock
25 mg$953-In Stock
1 mL x 10 mM (in DMSO)$345-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.59%
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Product Introduction

Bioactivity
Description
PIM1-IN-1 is a potent and highly selective PIM kinase inhibitor with strong preference for PIM1 and PIM3 over PIM2, effectively inhibiting BAD phosphorylation without detectable effects on FLT3 or hERG binding, and exhibiting antiproliferative and anticancer activity suitable for mechanistic studies of PIM-driven oncogenic signaling.
Targets&IC50
Pim1:7 nM, Pim3:70 nM, Pim2:5530 nM
In vitro
In the SKMEL-19 melanoma cell line, PIM1-IN-1 inhibited cell growth with a GI50 value of 1.48 μM. When cells were treated at concentrations of 2.5, 5, and 10 μM for 24 hours, the compound dose-dependently induced apoptosis[1].
In vivo
PIM1-IN-1 demonstrates acceptable clearance of 1.26 L/h/kg in BALB-C mice[1].
Chemical Properties
Molecular Weight474.56
FormulaC25H30N8O2
Cas No.1417630-95-5
SmilesN=1N=C2C=3OCCN(C3C=NN2C1C4=NC=5C(=CC=CC5NCC6CCNCC6)C=C4)CCOC
Relative Density.1.45 g/cm3 (Predicted)
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 36 mg/mL (75.86 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1072 mL10.5361 mL21.0722 mL105.3608 mL
5 mM0.4214 mL2.1072 mL4.2144 mL21.0722 mL
10 mM0.2107 mL1.0536 mL2.1072 mL10.5361 mL
20 mM0.1054 mL0.5268 mL1.0536 mL5.2680 mL
50 mM0.0421 mL0.2107 mL0.4214 mL2.1072 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PIM3PIM2PIM1-IN-1PIM-1-IN-1PIM1IN1PIM1 IN 1PIM1
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