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Anti-TopBP1 Polyclonal Antibody

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Catalog No. TMAB-13675

Anti-TopBP1 Polyclonal Antibody is a Rabbit antibody targeting TopBP1. Anti-TopBP1 Polyclonal Antibody can be used in WB.

Anti-TopBP1 Polyclonal Antibody

Anti-TopBP1 Polyclonal Antibody

😃Good
Catalog No. TMAB-13675
Anti-TopBP1 Polyclonal Antibody is a Rabbit antibody targeting TopBP1. Anti-TopBP1 Polyclonal Antibody can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2207-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5297-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-TopBP1 Polyclonal Antibody is a Rabbit antibody targeting TopBP1. Anti-TopBP1 Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Mouse (predicted:Human,Rat,Dog,Cow,Rabbit,Sheep)
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus. Cytoplasm; cytoskeleton; centrosome. Cytoplasm; cytoskeleton; spindle pole. Chromosome. Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AFX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation.
Tissue SpecificityHighly expressed in heart, brain, placenta, lung and kidney.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundRequired for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human TopBP1
Antigen Species
Human
Gene Name
TOPBP1
Gene ID
11073
Protein Name
DNA topoisomerase 2-binding protein 1
Uniprot ID
Q92547
Chemical Properties
Molecular WeightTheoretical: 171 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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