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(+)-Norfenfluramine hydrochloride
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Catalog No. T72114Cas No. 37936-89-3
(+)-Norfenfluramine hydrochloride, a significant liver metabolite of (+)-fenfluramine, functions as a selective agonist for the 5-HT 2B receptor (K i: 11.2 nM), effectively stimulating inositol phosphate hydrolysis and elevating intracellular Ca2+. It is utilized in research focusing on primary pulmonary hypertension and valvular heart disease.
(+)-Norfenfluramine hydrochloride
😃Good
Catalog No. T72114Cas No. 37936-89-3
(+)-Norfenfluramine hydrochloride, a significant liver metabolite of (+)-fenfluramine, functions as a selective agonist for the 5-HT 2B receptor (K i: 11.2 nM), effectively stimulating inositol phosphate hydrolysis and elevating intracellular Ca2+. It is utilized in research focusing on primary pulmonary hypertension and valvular heart disease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Product Introduction
Bioactivity
Chemical Properties
| Description | (+)-Norfenfluramine hydrochloride, a significant liver metabolite of (+)-fenfluramine, functions as a selective agonist for the 5-HT 2B receptor (K i: 11.2 nM), effectively stimulating inositol phosphate hydrolysis and elevating intracellular Ca2+. It is utilized in research focusing on primary pulmonary hypertension and valvular heart disease. |
| Targets&IC50 | 5-HT 2C Receptor:324 nM (Ki), 5-HT2B receptor:11.2 nM (Ki), 5-HT 2A Receptor:1516 nM (Ki) |
| Molecular Weight | 239.67 |
| Formula | C10H13ClF3N |
| Cas No. | 37936-89-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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