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PSB 1115

Catalog No. T23201 Copy Product Info
Purity: 99.39%
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PSB 1115 is an A2B receptor antagonist and can counteract the inhibitory effect of NECA.

PSB 1115

Copy Product Info
😃Good
Catalog No. T23201

PSB 1115 is an A2B receptor antagonist and can counteract the inhibitory effect of NECA.

PSB 1115
Cas No. 152529-79-8
Pack SizePriceUSA StockGlobal StockQuantity
1 mg$61In StockIn Stock
5 mgPreferentialIn StockIn Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.39%
Appearance:Solid
Color:White to Yellow
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Product Introduction

Bioactivity
Description
PSB 1115 is an A2B receptor antagonist and can counteract the inhibitory effect of NECA.
In vitro
PSB 1115 reversed the decrease in plasma insulin induced by NECA[1].
In vivo
The effect of PSB 1115 was obvious in diabetic GotoKakizaki rats: plasma insulin was increased whereas blood glucose was unchanged. The adenosine levels were not different in normal Wistar rats and in diabetic GotoKakzaki rats[1].
Chemical Properties
Molecular Weight350.35
FormulaC14H14N4O5S
Cas No.152529-79-8
SmilesO=C1C2=C(N=C(N2)C3=CC=C(S(=O)(=O)O)C=C3)NC(=O)N1CCC
Relative Density.1.522 g/cm3 (Predicted)
Storage & Solubility Information
StorageStore at low temperature | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: <38.84 mg/mL, Sonication is recommended.
H2O: <7.77 mg/mL, Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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