Shopping Cart

Your shopping cart is currently empty

SB220025

Name: SB220025
Brand: TargetMol
SKU: T28681
Price: 293 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T28681Cas No. 165806-53-1

Alias SB-220025, SB 220025

SB220025 is an orally available, selective and potent inhibitor of P38 mitogen-activated protein kinase that inhibits p56Lck and PKC, inhibits endothelial growth hormone-induced Ca(2+) signaling, and inhibits angiogenesis, and can be used in the study of arthritis.

SB220025

Copy Product Info

🥰Excellent

Purity: 99.44%

Catalog No. T28681Alias SB-220025, SB 220025Cas No. 165806-53-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$293	In Stock	In Stock
5 mg	$722	In Stock	In Stock
10 mg	$987	In Stock	In Stock
25 mg	$1,520	In Stock	In Stock
50 mg	$1,980	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.44%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	SB220025 is an orally available, selective and potent inhibitor of P38 mitogen-activated protein kinase that inhibits p56Lck and PKC, inhibits endothelial growth hormone-induced Ca(2+) signaling, and inhibits angiogenesis, and can be used in the study of arthritis.
Targets&IC50	p38 MAPK (human):60 nM, p56Lck:3.5 µM, PKC:2.89 µM
In vitro	SB220025 is an ATP-competitive and selective inhibitor of human p38 MAPK with an IC50 of 60 nM. p56Lck and PKC were also inhibited by SB220025 with IC50s of 3.5 and 2.89 µM, respectively. [2] SB220025 (20 μM; 6 h) significantly reduced IL-8 gene expression in HUVEC cells in response to globular adiponectin (gAd). [1]
In vivo	A single oral dose of 3-50 mg/kg SB220025 inhibited the production of inflammatory cytokines in vivo . Intraperitoneal administration of 5, 30, and 50 mg/kg SB220025 in a double dose inhibited angiogenesis in a mouse model of air sac granuloma . Oral administration of 30 mg/kg SB220025, given as a double dose for 3, 5, 7, or 14 days prevented the increase in angiogenesis after day 3 in the mouse air sac angiogenesis model . Oral administration of 50 mg/kg SB220025, double-dosed for 10 days, effectively inhibited the progression of arthritis in a chronic inflammatory disease model . [2]
Synonyms	SB-220025, SB 220025

Chemical Properties

Molecular Weight	338.38
Formula	C₁₈H₁₉FN₆
Cas No.	165806-53-1
Smiles	FC1=CC=C(C=C1)C=2N=CN(C2C=3N=C(N=CC3)N)C4CCNCC4
Relative Density.	1.42 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (295.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9553 mL	14.7763 mL	29.5526 mL	147.7629 mL
5 mM	0.5911 mL	2.9553 mL	5.9105 mL	29.5526 mL
10 mM	0.2955 mL	1.4776 mL	2.9553 mL	14.7763 mL
20 mM	0.1478 mL	0.7388 mL	1.4776 mL	7.3881 mL
50 mM	0.0591 mL	0.2955 mL	0.5911 mL	2.9553 mL
100 mM	0.0296 mL	0.1478 mL	0.2955 mL	1.4776 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc