BMP-4 Protein, Human, Recombinant (E399D)

Name: BMP-4 Protein, Human, Recombinant (E399D)
Brand: TargetMol
SKU: TMPY-06842
Price: 112 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: ZYME, OFC11, MCOPS6, bone morphogenetic protein 4, BMP2B1, BMP2B) Copy Product Info

Synonyms: ZYME, OFC11, MCOPS6, bone morphogenetic protein 4, BMP2B1, BMP2B

Catalog No. TMPY-06842 Copy Product Info

Purity: 95.9%

BMP-4 Protein, Human, Recombinant (E399D) is expressed in E. coli expression system. The predicted molecular weight is 13.25 kDa and the accession number is P12644.

Pack Size	Price	USA Stock	Global Stock
5 µg	$112	-	In Stock
10 µg	$183	7-10 days	7-10 days
20 µg	$306	In Stock	-
50 µg	$517	7-10 days	7-10 days
100 µg	$773	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:95.9%

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells. The ED50 for this effect is typically 0.08-0.4ug/mL.
Description	BMP-4 Protein, Human, Recombinant (E399D) is expressed in E. coli expression system. The predicted molecular weight is 13.25 kDa and the accession number is P12644.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	P12644
Construction	A DNA sequence encoding the human BMP4 (P12644) (Ser293-Arg408, E399D) was expressed. Predicted N terminal: Met
Protein Purity	≥ 95 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 30% Acetonitrile, 1/1000 TFA. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with 4 mM HCl to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	ZYME, OFC11, MCOPS6, bone morphogenetic protein 4, BMP2B1, BMP2B
Research Background	BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated through activating the JNK1/Bcl2 pathway. And the JNK1 inhibitor and knockdown of JNK1 could attenuate autophagy induced by BMP4 and eliminated BMP4-promoted HCC cells growth. BMP4 promoted HCC proliferation by autophagy activation through JNK1/Bcl-2 signaling.

Chemical Properties

Molecular Weight

13.25 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.