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VU6032735
Catalog No. T213165 Copy Product Info
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VU6032735 is a potent and subtype-selective inhibitor of the sperm-specific potassium channel 3 (SLO3), with IC50 values of 165 nM for human SLO3 (hSLO3) and 730 nM for mouse SLO3 (mSLO3). It also inhibits sodium channels and L-type calcium channels. VU6032735 maintains high tissue exposure in the oviduct post-fertilization and is used in contraceptive research.
VU6032735
Copy Product Info🥰Excellent
Catalog No. T213165
VU6032735 is a potent and subtype-selective inhibitor of the sperm-specific potassium channel 3 (SLO3), with IC50 values of 165 nM for human SLO3 (hSLO3) and 730 nM for mouse SLO3 (mSLO3). It also inhibits sodium channels and L-type calcium channels. VU6032735 maintains high tissue exposure in the oviduct post-fertilization and is used in contraceptive research.
VU6032735
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | VU6032735 is a potent and subtype-selective inhibitor of the sperm-specific potassium channel 3 (SLO3), with IC50 values of 165 nM for human SLO3 (hSLO3) and 730 nM for mouse SLO3 (mSLO3). It also inhibits sodium channels and L-type calcium channels. VU6032735 maintains high tissue exposure in the oviduct post-fertilization and is used in contraceptive research. |
| Targets&IC50 | SLO3 (human):165 nM |
| In vitro | VU6032735 at a concentration of 10 μM for 1-2 hours significantly inhibits hyperactivated motility of human sperm. Additionally, VU6032735 within the range of 0.01-1 μM can suppress mouse SLO3-γ2 channels in HEK293 cells. At 10 μM, VU6032735 also inhibits sodium channels and L-type calcium channels. |
| In vivo | When administered intraperitoneally at a dose of VU6032735 (10 mg/kg), the compound maintains a high level of tissue exposure in the ovaries, fallopian tubes, and uterus of female mice for up to 24 hours. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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