Powder: -20°C for 3 years | In solvent: -80°C for 1 year
p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α and IL-1β cytokine production (IC50s = 22 and 44 nM, respectively) in human peripheral blood mononuclear cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 35 days | $ 155.00 | |
10 mg | 35 days | $ 288.00 | |
25 mg | 35 days | $ 675.00 |
Description | p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α and IL-1β cytokine production (IC50s = 22 and 44 nM, respectively) in human peripheral blood mononuclear cells. |
Targets&IC50 | p38β:0.55 μM (IC50), p38α:0.13 μM (IC50), p38χ:5.47 μM (IC50), p38δ:8.63 μM (IC50) |
Synonyms | p38 MAPK Inhibitor IV |
Molecular Weight | 456.94 |
Formula | C12H4Cl6O4S |
CAS No. | 1638-41-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.5 mg/mL
DMF: 2 mg/mL
You can also refer to dose conversion for different animals. More
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p38 MAP Kinase Inhibitor IV 1638-41-1 p-38 MAP Kinase Inhibitor IV p38 MAPK Inhibitor IV inhibitor inhibit