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Anti-AACT Antibody (1F833)
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Catalog No. TMAB-02123
Anti-AACT Antibody (1F833) is a Rabbit antibody targeting AACT. Anti-AACT Antibody (1F833) can be used in WB,IHC-P,IHC-Fr,IF.
Anti-AACT Antibody (1F833)
Anti-AACT Antibody (1F833)
😃Good
Catalog No. TMAB-02123
Anti-AACT Antibody (1F833) is a Rabbit antibody targeting AACT. Anti-AACT Antibody (1F833) can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $149 | 7-10 days | 7-10 days | |
| 50 μL | $261 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-AACT Antibody (1F833) is a Rabbit antibody targeting AACT. Anti-AACT Antibody (1F833) can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Clone | 1F833 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:2000-10000; IHC-P: 1:200-800; IHC-Fr: 1:200-800; IF: 1:200-800 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted. |
| Tissue Specificity | Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Lyophilized or Liquid |
| Formulation | PBS, Glycerol, BSA. |
| Concentration | 1mg/ml |
| Research Background | Alpha 1-Antichymotrypsin, a member of the serine proteinase inhibitor (serpin) family, inhibits neutrophil proteinase cathepsin G and mast cell chymases, and protects the lower respiratory tract from damage by proteolytic enzymes. It contains a reactive centre loop, which interacts with cognate proteinases, resulting in loop cleavage and a major conformational change. Recently, alpha 1-antichymotrypsin has been identified as a major constituent of the neurofibrillary plaques associated with Alzheimers disease, and in vitro studies have shown that it enhances the rate of amyloid-fibril formation. These observations and recent genetic evidence suggest that alpha 1-antichymotrypsin is important in the pathogenesis of Alzheimers disease. |
| Immunogen | Full length native Protein |
| Antigen Species | Human |
| Gene Name | SERPINA3 |
| Gene ID | |
| Protein Name | alpha-1-antichymotrypsin |
| Uniprot ID | |
| Function | Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. |
| Molecular Weight | Theoretical: 45 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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