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11β-HSD1 inibitor 17

Name: 11β-HSD1 inibitor 17
Brand: TargetMol
SKU: T67903
Price: 109 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67903Cas No. 946394-50-9

11β-HSD1 inibitor 17 is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).

11β-HSD1 inibitor 17

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Purity: 99.72%

Catalog No. T67903Cas No. 946394-50-9

11β-HSD1 inibitor 17 is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$109	In Stock	In Stock
5 mg	$270	In Stock	In Stock
10 mg	$383	In Stock	In Stock
25 mg	$575	In Stock	In Stock
50 mg	$777	In Stock	In Stock
100 mg	$1,050	In Stock	In Stock
200 mg	$1,370	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.72%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

11β-HSD1 inibitor 17 AI Summary

11β-HSD1 inibitor 17 exhibits inhibitory bioactivity against human recombinant 11beta-HSD1, with an IC50 of 74.0 nM in one assay and 603.0 nM in another assay. However, the compound shows reduced activity against mouse recombinant 11beta-HSD1, with an IC50 greater than 1000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

11β-HSD1 inibitor 17 is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).

Chemical Properties

Molecular Weight	447.47
Formula	C₂₂H₂₀F₃N₃O₂S
Cas No.	946394-50-9
Smiles	C(F)(F)(F)C1=C(N=CC=C1)N2CCN(S(=O)(=O)C3=CC=C(C=C3)C4=CC=CC=C4)CC2
Relative Density.	1.347 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (111.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2348 mL	11.1739 mL	22.3479 mL	111.7393 mL
5 mM	0.4470 mL	2.2348 mL	4.4696 mL	22.3479 mL
10 mM	0.2235 mL	1.1174 mL	2.2348 mL	11.1739 mL
20 mM	0.1117 mL	0.5587 mL	1.1174 mL	5.5870 mL
50 mM	0.0447 mL	0.2235 mL	0.4470 mL	2.2348 mL
100 mM	0.0223 mL	0.1117 mL	0.2235 mL	1.1174 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc