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Gardiquimod

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Catalog No. T15371Cas No. 1020412-43-4

Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells. Gardiquimod is an imidazoquinoline analog and is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7.

Gardiquimod
Other Forms of Gardiquimod:

Gardiquimod

🥰Excellent
Purity: 99.68%
Catalog No. T15371Cas No. 1020412-43-4
Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells. Gardiquimod is an imidazoquinoline analog and is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$40In StockIn Stock
10 mg$64In StockIn Stock
25 mg$147In StockIn Stock
50 mgPreferential-In Stock
1 mL x 10 mM (in DMSO)$44In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.68%
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Product Introduction

Bioactivity
Description
Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells. Gardiquimod is an imidazoquinoline analog and is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7.
In vitro
Administration of 6-60?μM Gardiquimod obviously inhibits HIV-1 reverse transcriptase cDNA synthesis[1].
In vivo
Gardiquimod (1 mg/kg per mouse; i.p.; daily for 7 days) in combination with Dendritic cells (DCs) enhance the anti-tumor effects of NK cells[2].
Chemical Properties
Molecular Weight313.4
FormulaC17H23N5O
Cas No.1020412-43-4
SmilesCCNCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O
Relative Density.1.29 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (143.59 mM), Sonication is recommended.
DMF: 18 mg/mL (57.43 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (6.38 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMF/DMSO
1mg5mg10mg50mg
1 mM3.1908 mL15.9541 mL31.9081 mL159.5405 mL
5 mM0.6382 mL3.1908 mL6.3816 mL31.9081 mL
10 mM0.3191 mL1.5954 mL3.1908 mL15.9541 mL
20 mM0.1595 mL0.7977 mL1.5954 mL7.9770 mL
50 mM0.0638 mL0.3191 mL0.6382 mL3.1908 mL
DMSO
1mg5mg10mg50mg
100 mM0.0319 mL0.1595 mL0.3191 mL1.5954 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Toll-like Receptor (TLR)TLR8TLR7peripheralPBMCsmononuclearmacrophagesliverInhibitorinhibitHuman immunodeficiency virusHIVProteaseHIV-1HIV ProteaseHIVHepG2Gardiquimodcellscarcinomablood
Related Tags: buy Gardiquimod | purchase Gardiquimod | Gardiquimod cost | order Gardiquimod | Gardiquimod chemical structure | Gardiquimod in vivo | Gardiquimod in vitro | Gardiquimod formula | Gardiquimod molecular weight
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