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dBET1

dBET1
dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.
Catalog No. T4495Cas No. 1799711-21-9
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Purity:99.3%
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dBET1

Catalog No. T4495Cas No. 1799711-21-9

dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.
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Pack SizePriceAvailabilityQuantity
1 mg$48In Stock
2 mg$67In Stock
5 mg$97In Stock
10 mg$178In Stock
25 mg$372In Stock
50 mg$556In Stock
100 mg$783In Stock
500 mg$1,650In Stock
1 mL x 10 mM (in DMSO)$155In Stock
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Product Introduction

Bioactivity
Description
dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.
Targets&IC50
BET:430 nM (EC50)
In vitro
dBET1 induced a potent and superior inhibitory effect on MV4;11 cell proliferation at 24 hours (measured by ATP content, IC50 = 0.14 μM, compared to IC50 = 1.1 μM with JQ1) consistent with the reported, pronounced inhibitory effect of RNA silencing of BRD4 in this and other models of MLL-rearranged leukemia.
Chemical Properties
Molecular Weight785.27
FormulaC38H37ClN8O7S
Cas No.1799711-21-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL
H2O: Insoluble
Ethanol: 5 mg/mL

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