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Anti-LAIR1 Antibody (3K641)
😃Good
Catalog No. TMAY-03527
Alias leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, CD305
Anti-LAIR1 Antibody (3K641) is a Rabbit antibody targeting LAIR1. Anti-LAIR1 Antibody (3K641) can be used in ELISA.
Anti-LAIR1 Antibody (3K641)
Anti-LAIR1 Antibody (3K641)
😃Good
Catalog No. TMAY-03527Alias leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, CD305
Anti-LAIR1 Antibody (3K641) is a Rabbit antibody targeting LAIR1. Anti-LAIR1 Antibody (3K641) can be used in ELISA.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 μL | $268 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-LAIR1 Antibody (3K641) is a Rabbit antibody targeting LAIR1. Anti-LAIR1 Antibody (3K641) can be used in ELISA. |
| Synonyms | leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, CD305 |
| Ig Type | Rabbit IgG |
| Clone | 3K641 |
| Reactivity | Mouse |
| Specificity | Mouse LAIR1 |
| Application | |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse LAIR-1 / CD305 (rM LAIR-1 / CD305; TMPY-02598; Q8BG84-1; Gln22-Ser133). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Leukocyte-associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and can spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Mouse LAIR-1 / CD305 Protein (TMPY-02598) |
| Antigen Species | Mouse |
| Biology Area | ITIM/ITAM Immunoreceptors and Related Molecules |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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