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Anti-LAIR1 Antibody (3K641)

😃Good
Catalog No. TMAY-03527
Alias leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, CD305

Anti-LAIR1 Antibody (3K641) is a Rabbit antibody targeting LAIR1. Anti-LAIR1 Antibody (3K641) can be used in ELISA.

Anti-LAIR1 Antibody (3K641)

Anti-LAIR1 Antibody (3K641)

😃Good
Catalog No. TMAY-03527Alias leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, CD305
Anti-LAIR1 Antibody (3K641) is a Rabbit antibody targeting LAIR1. Anti-LAIR1 Antibody (3K641) can be used in ELISA.
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100 μL$268 7-10 days
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Product Introduction

Bioactivity
Description
Anti-LAIR1 Antibody (3K641) is a Rabbit antibody targeting LAIR1. Anti-LAIR1 Antibody (3K641) can be used in ELISA.
Aliasleukocyte-associated immunoglobulin-like receptor 1, LAIR-1, CD305
Ig Type
Monoclonal Rabbit IgG
Clone
3K641
Reactivity
Mouse
Application
ELISA
Recommended Dose
ELISA: 1:5000-1:10000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Mouse LAIR-1 / CD305 (rM LAIR-1 / CD305; TMPY-02598; Q8BG84-1; Gln22-Ser133).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundLeukocyte-associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and can spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Mouse LAIR-1 / CD305 Protein (TMPY-02598)
Antigen Species
Mouse
Biology Area
ITIM/ITAM Immunoreceptors and Related Molecules
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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