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Anti-LAIR1 Antibody (3K641) is a Rabbit antibody targeting LAIR1. Anti-LAIR1 Antibody (3K641) can be used in ELISA.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μL | $268 | 7-10 days |
Description | Anti-LAIR1 Antibody (3K641) is a Rabbit antibody targeting LAIR1. Anti-LAIR1 Antibody (3K641) can be used in ELISA. |
Alias | leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, CD305 |
Ig Type | Monoclonal Rabbit IgG |
Clone | 3K641 |
Reactivity | Mouse |
Application | ELISA |
Recommended Dose | ELISA: 1:5000-1:10000 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse LAIR-1 / CD305 (rM LAIR-1 / CD305; TMPY-02598; Q8BG84-1; Gln22-Ser133). |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | Leukocyte-associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and can spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells. |
Conjucates | Unconjugated |
Immunogen | Recombinant Mouse LAIR-1 / CD305 Protein (TMPY-02598) |
Antigen Species | Mouse |
Biology Area | ITIM/ITAM Immunoreceptors and Related Molecules |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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