Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Emlenoflast sodium

Name: Emlenoflast sodium
Brand: TargetMol
SKU: T9222L
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T9222LCas No. 2380032-29-9

Alias MCC7840 sodium

Emlenoflast sodium (MCC7840 sodium), a sulfonylurea, is a selective NLRP3 inflammasome inhibitor with an IC50 value of less than 100 nM for NLRP3 inflammasome, and can be used in the study of inflammatory diseases.

Emlenoflast sodium

Copy Product Info

😃Good

Catalog No. T9222LAlias MCC7840 sodiumCas No. 2380032-29-9

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	Inquiry	5 days	5 days
5 mg	$970	5 days	5 days
25 mg	Inquiry	6-8 weeks	6-8 weeks
50 mg	Inquiry	6-8 weeks	6-8 weeks
100 mg	Inquiry	6-8 weeks	6-8 weeks

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	Emlenoflast sodium (MCC7840 sodium), a sulfonylurea, is a selective NLRP3 inflammasome inhibitor with an IC50 value of less than 100 nM for NLRP3 inflammasome, and can be used in the study of inflammatory diseases.
Targets&IC50	NLRP3 inflammasome:<100 nM
In vitro	Emlenoflast sodium is an MCC950 analogue that exhibits useful activity in inhibiting NLRP3 inflammasome activation with IC50 <100 nM.[1]
In vivo	Emlenoflast sodium (4 mg/kg; i.v.; Male C57BL/6 mice) showed t1/2=3.39 h; AUC0-last=107097 ng•h/mL; CL=0.621 mL /min/kg.[2] Emlenoflast sodium (20 mg/kg; p.o.; Male C57BL/6 mice) exhibits good oral bioavailability (67.2%), Cmax (60467 ng/mL) and half-life (5.02 h) in mice.[2]
Synonyms	MCC7840 sodium

Chemical Properties

Molecular Weight	411.47
Formula	C₁₉H₂₄N₄NaO₃S
Cas No.	2380032-29-9
Smiles	[Na].O=C(NC=1C2=C(C=C3C1CCC3)CCC2)NS(=O)(=O)C4=NN(C=C4)C(C)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 216 mg/mL (524.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (12.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4303 mL	12.1516 mL	24.3031 mL	121.5155 mL
5 mM	0.4861 mL	2.4303 mL	4.8606 mL	24.3031 mL
10 mM	0.2430 mL	1.2152 mL	2.4303 mL	12.1516 mL
20 mM	0.1215 mL	0.6076 mL	1.2152 mL	6.0758 mL
50 mM	0.0486 mL	0.2430 mL	0.4861 mL	2.4303 mL
100 mM	0.0243 mL	0.1215 mL	0.2430 mL	1.2152 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc