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Anti-CD44 Antibody-PE (7W954)
🥰Excellent
Catalog No. TMAY-02283P
Anti-CD44 Antibody-PE (7W954) is a PE-conjugated Mouse antibody targeting CD44. Anti-CD44 Antibody-PE (7W954) can be used in FCM.
Anti-CD44 Antibody-PE (7W954)
Anti-CD44 Antibody-PE (7W954)
🥰Excellent
Catalog No. TMAY-02283P
Anti-CD44 Antibody-PE (7W954) is a PE-conjugated Mouse antibody targeting CD44. Anti-CD44 Antibody-PE (7W954) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD44 Antibody-PE (7W954) is a PE-conjugated Mouse antibody targeting CD44. Anti-CD44 Antibody-PE (7W954) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 7W954 |
| Reactivity | Human |
| Verified Activity | Profile of peripheral blood lymphocytes analyzed by flow cytometry. The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable lymphocytes. |
| Application | FCM |
| Recommended Dose | 1 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD44 (rh CD44; TMPY-02033; P16070-1; Met 1-Pro 220) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | CD44 is a type I transmembrane protein and a member of the cartilage link protein family. It is involved in cell-cell and cell-matrix interactions and signal transduction. Several CD44 ligands have been identified. The most extensively characterized ligand for CD44 is hyaluronan, a component of the extracellular matrix. CD44 protein is expressed on the majority of immune cells. The binding of CD44 to hyaluronan is induced on T lymphocytes after activation by antigen and on monocytes after stimulation by inflammatory agents. Under inflammatory conditions, CD44 on endothelial cells presents hyaluronan to CD44 on activated T lymphocytes and mediates a rolling interaction under flow conditions. Perturbations of the hyaluronan-CD44 interaction at the plasma membrane by various antagonists result in attenuation of receptor tyrosine kinase and transporter activities and inhibition of tumor progression in vivo. CD44 is known to interact with the ezrin family (ERM family) members and form a complex that plays diverse roles within both normal and abnormal cells, particularly cancer cells. CD44 and ezrin and their respective complex have properties suggesting that they may be important in the process of tumour-endothelium interactions, cell migrations, cell adhesion, tumour progression and metastasis. |
| Conjucates | PE |
| Others Formats | Unconjugated/APC/PerCP/FITC |
| Antibody Types Available | 5 |
| Immunogen | Recombinant Human CD44 protein (TMPY-02033) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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