Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activity and dimerisation and has potent activity against multiple protease inhibitor (PI) HIV-1 isolates (IC50 of 66-410 nM). Tipranavir inhibits SARS-CoV-2 3CLpro activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 125.00 | |
5 mg | In stock | $ 397.00 | |
10 mg | In stock | $ 597.00 | |
25 mg | In stock | $ 935.00 | |
50 mg | In stock | $ 1,260.00 | |
100 mg | In stock | $ 1,690.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 527.00 |
Description | Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activity and dimerisation and has potent activity against multiple protease inhibitor (PI) HIV-1 isolates (IC50 of 66-410 nM). Tipranavir inhibits SARS-CoV-2 3CLpro activity. |
Targets&IC50 | HIV-1 (isolates):66-410 nM, HIV-1 (isolates):8 pM(Ki ) |
In vitro | Tipranavir (PNU-140690) inhibits the enzymatic activity of HIV-1 protease, blocks the dimerization of protease subunits, and exerts potent activity against a wide spectrum of wild-type and multi-PI-resistant HIV-1 variants.[1] |
In vivo |
Tipranavir (5 mg/kg ; mouse model): CLtot was 0.17 ± 0.10 L/h/kg, Vss was 0.51 ± 0.14 L/kg, and t1/2 was 5.4 ±0. 3h.[4] Tipranavir (10 mg/kg ; oral ; rats): got the result of F was 30% compared to 5 mg/kg tipranavir dosing.[4] |
Synonyms | PNU-140690 |
Molecular Weight | 602.66 |
Formula | C31H33F3N2O5S |
CAS No. | 174484-41-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 45.0 mg/mL (74.7 mM)
DMSO: 180.0 mg/mL (298.7 mM ), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Tipranavir 174484-41-4 Microbiology/Virology Proteases/Proteasome HIV Protease SARS-CoV PNU 140690 PNU140690 PNU-140690 inhibitor inhibit