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MCP110

Name: MCP110
Brand: TargetMol
SKU: T24437
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24437Cas No. 521310-51-0

Alias MCP-110, MCP 110

MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.

MCP110

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Purity: 97.23%

Catalog No. T24437Alias MCP-110, MCP 110Cas No. 521310-51-0

MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	-	In Stock
5 mg	$98	-	In Stock
10 mg	$172	-	In Stock
25 mg	$307	-	In Stock
50 mg	$445	-	In Stock
100 mg	$592	-	In Stock
500 mg	$1,180	-	In Stock
1 mL x 10 mM (in DMSO)	$110	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.23%

Appearance:Liquid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.
In vitro	In A549 cells, MCP110 (20 μM) decreases Ras stimulation of Raf-1 and cyclin D level stimulated by the treatment with EGF (100 ng/mL), platelet-derived growth factor (20 ng/mL), and serum. In in HEK293 cells, MCP110 (10 and 20 μM) inhibits H-Ras (V12)-induced AP-1 activation. In fibrosarcoma HT1080 cells, MCP110 (1, 2, 5, 10, and 20 μM) shows a dose-dependent inhibition of elevated Raf-1 activity[1].
Synonyms	MCP-110, MCP 110

Chemical Properties

Molecular Weight	508.65
Formula	C₃₃H₃₆N₂O₃
Cas No.	521310-51-0
Smiles	COc1cc(CN(CCc2ccccn2)C(=O)CCCCc2ccccc2)ccc1OCc1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (481.67 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9660 mL	9.8299 mL	19.6599 mL	98.2994 mL
5 mM	0.3932 mL	1.9660 mL	3.9320 mL	19.6599 mL
10 mM	0.1966 mL	0.9830 mL	1.9660 mL	9.8299 mL
20 mM	0.0983 mL	0.4915 mL	0.9830 mL	4.9150 mL
50 mM	0.0393 mL	0.1966 mL	0.3932 mL	1.9660 mL
100 mM	0.0197 mL	0.0983 mL	0.1966 mL	0.9830 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc