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SERCA2a activator 1

Name: SERCA2a activator 1
Brand: TargetMol
SKU: T16873
Price: 197 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16873Cas No. 2139330-34-8

SERCA2a activator 1 is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a activator. SERCA2a activator 1 decreases phospholamban inhibition and enhances the systolic and diastolic functions of the heart.

SERCA2a activator 1

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Purity: 99.75%

Catalog No. T16873Cas No. 2139330-34-8

Pack Size	Price	Availability
1 mg	$197	In Stock
5 mg	$496	In Stock
10 mg	$695	In Stock
25 mg	$1,090	In Stock
50 mg	$1,560	In Stock
100 mg	$2,180	In Stock
1 mL x 10 mM (in DMSO)	$593	In Stock

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Purity:99.75%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	SERCA2a activator 1 is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a activator. SERCA2a activator 1 decreases phospholamban inhibition and enhances the systolic and diastolic functions of the heart.
In vitro	SERCA2a activator 1 activates the Ca2+-dependent ATPase activity of cardiac sarcoplasmic reticulum vesicles but not that of skeletal muscle SR vesicles that lack phospholamban. SERCA2a activator 1 also increases the Ca2+ transients and contraction and relaxation of isolated adult rat cardiomyocytes. The surface plasmon resonance assay reveals a direct interaction between SERCA2a activator 1 and PLN, suggesting that the binding of SERCA2a activator 1 to PLN attenuates its inhibition of SERCA2a, resulting in SERCA2a activation [1].
In vivo	SERCA2a activator 1 (30mg/kg; intravenous injection; male Wistar rats) treatment obviously increases the diastolic function in anesthetized normal rats [1].

Chemical Properties

Molecular Weight	551.66
Formula	C₃₂H₂₉N₃O₄S
Cas No.	2139330-34-8
Smiles	CCCCn1cc(cc(Cc2ccccc2)c1=O)-c1cc(ccn1)C(=O)NS(=O)(=O)c1ccc2ccccc2c1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (108.76 mM), Sonication and heating to 80℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8127 mL	9.0636 mL	18.1271 mL	90.6355 mL
5 mM	0.3625 mL	1.8127 mL	3.6254 mL	18.1271 mL
10 mM	0.1813 mL	0.9064 mL	1.8127 mL	9.0636 mL
20 mM	0.0906 mL	0.4532 mL	0.9064 mL	4.5318 mL
50 mM	0.0363 mL	0.1813 mL	0.3625 mL	1.8127 mL
100 mM	0.0181 mL	0.0906 mL	0.1813 mL	0.9064 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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